Epidemiology of adverse drug reactions in Europe: a review of recent observational studies.
Epidemiology of adverse drug reactions in Europe: a review of recent observational studies.
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DOI：
10.1007/s40264-015-0281-0
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发表时间：
2015-05
期刊：
影响因子：
4.2
通讯作者：
Koopmanschap, Marc A.
中科院分区：
文献类型：
--
作者：
Bouvy, Jacoline C.;De Bruin, Marie L.;Koopmanschap, Marc A.
药物不良反应(ADR)会导致相当大的死亡率和发病率，但目前还没有欧洲地区的最新综述。因此，我们对2000年1月1日至2014年9月3日期间在欧洲发表的所有量化ADR的流行病学研究进行了审查。包括评估因ADR而住院的患者数量的研究，评估住院期间出现ADR的患者数量的研究，以及在门诊环境中衡量ADR的研究。总共有47篇文章被纳入最终审查。基于22项研究，因ADR住院的中位数百分比为3.5%，基于13项研究，住院期间经历ADR的患者中位数百分比为10.1%。只有5项研究发现，评估的不良反应发生在门诊环境中。这些结果表明，在欧洲医院环境中发生的不良反应--无论是导致住院的不良反应还是发生在住院期间的不良反应--都是显著的。此外，在门诊环境下进行的有限数量的研究发现，在这种环境下缺乏关于ADR流行病学的信息。
Adverse drug reactions (ADRs) cause considerable mortality and morbidity but no recent reviews are currently available for the European region. Therefore, we performed a review of all epidemiological studies quantifying ADRs in a European setting that were published between 1 January 2000 and 3 September 2014. Included studies assessed the number of patients who were admitted to hospital due to an ADR, studies that assessed the number of patients who developed an ADR during hospitalization, and studies that measured ADRs in the outpatient setting. In total, 47 articles were included in the final review. The median percentage of hospital admissions due to an ADR was 3.5 %, based on 22 studies, and the median percentage of patients who experienced an ADR during hospitalization was 10.1 %, based on 13 studies. Only five studies were found that assessed ADRs occurring in the outpatient setting. These results indicate that the occurrence of ADRs in the European hospital setting—both ADRs that result in hospitalization and ADRs that occur during the hospital stay—is significant. Furthermore, the limited number of studies that were performed in the outpatient setting identify a lack of information regarding the epidemiology of ADRs in this setting.
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影响因子：
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作者：
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通讯作者：
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