A mutation of the circadian timing system (tau gene) in the seasonally breeding Syrian hamster alters the reproductive response to photoperiod change
A mutation of the circadian timing system (tau gene) in the seasonally breeding Syrian hamster alters the reproductive response to photoperiod change
复制标题
季节性繁殖的叙利亚仓鼠的昼夜节律系统（tau 基因）突变改变了对光周期变化的生殖反应
DOI：
--
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
A. Loudon
中科院分区：
文献类型：
--
作者：
J. Stirland;Y. Mohammad;A. Loudon
tau突变是一种半显性常染色体突变，在纯合子中，其使昼夜活动周期加快约4 h。在哺乳动物中，昼夜节律系统通过在黑暗的几个小时期间产生重复的每日褪黑激素信号而有助于季节性光周期时间测量。我们早期的研究表明tau突变体对褪黑激素信号的反应发生了改变。这项研究调查了tau蛋白和野生型仓鼠是否表现出对光周期变化的差异反应。繁殖活跃的动物在暴露于夜间长度增加至9、10、11、12或14 h之前，维持在每24 h（野生型）16 h光照（16 L）或每20 h（tau）12 L的刺激性光周期下，持续84个周期。野生型在13 L：11 Dark（13 L：11 D）下表现出睾丸萎缩，在12 L：12 D的光周期下完全消退。Taus表现出完整的回归，包括10小时黑暗或更长的每20小时周期的光时间表。血浆催乳素浓度降低暴露后，至少9和10小时的黑暗中，牛和野生型，分别。因此，tau基因型可能表现出不同的临界夜长相对于性腺和催乳素轴，约1-2小时短于野生型基因型。这些数据支持这样的假设，即昼夜节律tau突变改变了光周期时间测量的基础，可能是通过改变褪黑激素信号的产生和/或解释。
The tau mutation is a semi-dominant autosomal mutation which, in homozygotes, accelerates the period of the circadian activity cycle by approximately 4 h. In mammals, the circadian system contributes to seasonal photoperiodic time measurement by generating a repeated daily melatonin signal during the hours of darkness. Our earlier studies suggest an altered response to the melatonin signal in tau mutants. This study investigated whether tau and wild-type hamsters exhibit a differential response to photoperiod change. Reproductively active animals were maintained on stimulatory photoperiods of 16 h light (16L) per 24 h (wild-type) or 12L per 20 h (tau) before being exposed to an increase in night-length to 9, 10, 11, 12 or 14 h for 84 cycles. Wild-types exhibited testicular atrophy at 13L: 11Dark (13L: 11D), with full regression at photoperiods of 12L: 12D. Taus exhibited complete regression at photoschedules comprising 10 h darkness or more per 20-h cycle. Plasma prolactin concentrations were decreased following exposure to at least 9 and 10 h darkness in taus and wild-types, respectively. Thus, the tau genotype may exhibit a different critical night-length with respect to both the gonadal and prolactin axes, of approximately 1-2 h shorter than wild-type genotypes. These data support the hypothesis that the circadian tau mutation has altered the basis of photoperiodic time measurement, perhaps by altering the generation and/or interpretation of the melatonin signal.
影响因子：
56.9
作者：
RALPH, MR;MENAKER, M
通讯作者：
MENAKER, M
金仓鼠 (Mesocricetus auratus) 的近交系之间的光周期反应有所不同。
影响因子：
3.6
作者：
Vitaterna,MH;Turek,FW
通讯作者：
Turek,FW
自由奔跑和夹带叙利亚仓鼠的血液和松果体中褪黑激素的昼夜节律和每日节律。
DOI：
10.1677/joe.0.1360065
发表时间：
1993
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Maywood,ES;Hastings,MH;Max,M;Ampleford,E;Menaker,M;Loudon,AS
通讯作者：
Loudon,AS