Hitting the Target: How T Cells Detect and Eliminate Tumors.
Hitting the Target: How T Cells Detect and Eliminate Tumors.
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DOI：
10.4049/jimmunol.1701413
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发表时间：
2018-01-15
期刊：
影响因子：
--
通讯作者：
Thomas PG
中科院分区：
文献类型：
--
作者：
Zamora AE;Crawford JC;Thomas PG
The successes of anti-tumor immuno-based therapies and the application of next-generation sequencing to mutation profiling have produced insights into the specific targets of anti-tumor T cells. Mutated proteins have tremendous potential as targets for interventions using autologous T cells or engineered cell therapies and may serve as important correlates of efficacy for immunoregulatory interventions including immune checkpoint blockade (ICB). As mutated self, tumors present an exceptional case for host immunity, which has primarily evolved in response to foreign pathogens. Tumor antigens’ resemblance to self may limit immune recognition, but key features appear to be the same between anti-pathogen and anti-tumor responses. Determining which targets will make efficacious antigens and which responses might be elicited therapeutically are key questions for the field. Here we discuss current knowledge on anti-tumor specificity, the mutations that provide immunogenic targets, and how cross-reactivity and immunodominance may contribute to variation in immune responses among tumor types.
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