Vascular permeability, vascular hyperpermeability and angiogenesis.
Vascular permeability, vascular hyperpermeability and angiogenesis.
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DOI：
10.1007/s10456-008-9099-z
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发表时间：
2008
期刊：
影响因子：
9.8
通讯作者：
Dvorak, Harold F.
中科院分区：
文献类型：
--
作者：
Nagy, Janice A.;Benjamin, Laura;Zeng, Huiyan;Dvorak, Ann M.;Dvorak, Harold F.
关键词：
血管系统具有为组织提供营养和清除废物的关键功能。为了实现这些目标，脉管系统必须具有足够的渗透性，以允许小分子和气体以及在较小程度上允许血浆蛋白自由双向通过。生理学家和许多血管生物学家对血管通透性的定义和测量方法存在分歧。我们回顾这些相互冲突的观点，发现两者都提供了有用但互补的信息。在急性和慢性炎症、癌症和伤口愈合中，任何测量的血管渗透性都显著增加。这种高通透性是由急性或慢性暴露于血管透化剂，特别是血管通透性因子/血管内皮生长因子（VPF/VEGF，VEGF-A）介导的。我们证明，三种明显不同类型的血管通透性可以区分，基于不同类型的微血管参与，外渗物的成分，以及不同大小的分子穿过血管内皮的解剖途径。这些是正常组织的基础血管通透性（BVP）、响应于VEGF-A或其他血管透化剂的单次短暂暴露而发生的急性血管通透性过高（AVH）、以及表征病理性血管生成的慢性血管通透性过高（CVH）。最后，我们列出了许多（至少25）基因产物，不同的作者已经发现，影响血管通透性的各种工程小鼠和分类，他们的参与，尽可能，在BVP，AVH和CVH。需要进一步的工作来阐明这些分子和其他可能被发现的分子介导不同类型的血管通透性的信号通路。
The vascular system has the critical function of supplying tissues with nutrients and clearing waste products. To accomplish these goals, the vasculature must be sufficiently permeable to allow the free, bidirectional passage of small molecules and gases and, to a lesser extent, of plasma proteins. Physiologists and many vascular biologists differ as to the definition of vascular permeability and the proper methodology for its measurement. We review these conflicting views, finding that both provide useful but complementary information. Vascular permeability by any measure is dramatically increased in acute and chronic inflammation, cancer, and wound healing. This hyperpermeability is mediated by acute or chronic exposure to vascular permeabilizing agents, particularly vascular permeability factor/vascular endothelial growth factor (VPF/VEGF, VEGF-A). We demonstrate that three distinctly different types of vascular permeability can be distinguished, based on the different types of microvessels involved, the composition of the extravasate, and the anatomic pathways by which molecules of different size cross-vascular endothelium. These are the basal vascular permeability (BVP) of normal tissues, the acute vascular hyperpermeability (AVH) that occurs in response to a single, brief exposure to VEGF-A or other vascular permeabilizing agents, and the chronic vascular hyperpermeability (CVH) that characterizes pathological angiogenesis. Finally, we list the numerous (at least 25) gene products that different authors have found to affect vascular permeability in variously engineered mice and classify them with respect to their participation, as far as possible, in BVP, AVH and CVH. Further work will be required to elucidate the signaling pathways by which each of these molecules, and others likely to be discovered, mediate the different types of vascular permeability.
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影响因子：
82.9
作者：
Chen, JH;Somanath, PR;Byzova, TV
通讯作者：
Byzova, TV
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82.9
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影响因子：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
CARVALHO, AC