Greater BOLD variability in older compared with younger adults during audiovisual speech perception.
Greater BOLD variability in older compared with younger adults during audiovisual speech perception.
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DOI：
10.1371/journal.pone.0111121
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Beauchamp MS
中科院分区：
文献类型：
--
作者：
Baum SH;Beauchamp MS
老年人在一系列认知任务（包括言语感知）上表现出表现下降和试验间变异性增加。我们使用血氧水平依赖的功能磁共振成像（BOLD fMRI）来寻找这些行为现象的神经相关性。我们比较了24名健康老年人（53 - 70岁）和14名年轻人（23 - 39岁）对简单语音刺激（视听音节）的大脑反应，使用两种独立的分析策略：感兴趣区域（ROI）和体素全脑分析。虽然年轻人的平均反应幅度稍大，但老年人的受试者内部变异性要大得多。在老年人中，在全脑分析中观察到个体体素和左颞上沟、左听觉皮层和左视觉皮层的roi显著增加。老年人的变异性增加不能归因于两组之间头部运动的差异。随着年龄的增长，神经变异性的增加可能与表现下降和行为变异性的增加有关。
Older adults exhibit decreased performance and increased trial-to-trial variability on a range of cognitive tasks, including speech perception. We used blood oxygen level dependent functional magnetic resonance imaging (BOLD fMRI) to search for neural correlates of these behavioral phenomena. We compared brain responses to simple speech stimuli (audiovisual syllables) in 24 healthy older adults (53 to 70 years old) and 14 younger adults (23 to 39 years old) using two independent analysis strategies: region-of-interest (ROI) and voxel-wise whole-brain analysis. While mean response amplitudes were moderately greater in younger adults, older adults had much greater within-subject variability. The greatly increased variability in older adults was observed for both individual voxels in the whole-brain analysis and for ROIs in the left superior temporal sulcus, the left auditory cortex, and the left visual cortex. Increased variability in older adults could not be attributed to differences in head movements between the groups. Increased neural variability may be related to the performance declines and increased behavioral variability that occur with aging.
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影响因子：
2.4
作者：
Divenyi, PL;Stark, PB;Haupt, KM
通讯作者：
Haupt, KM
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
3.7
作者：
Anderson S;Parbery-Clark A;Yi HG;Kraus N
通讯作者：
Kraus N
影响因子：
16.2
作者：
Beck JM;Ma WJ;Pitkow X;Latham PE;Pouget A
通讯作者：
Pouget A
DOI：
10.1523/jneurosci.2176-12.2012
发表时间：
2012-10-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Anderson S;Parbery-Clark A;White-Schwoch T;Kraus N
通讯作者：
Kraus N