Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis.
Autophagy in the pathogenesis and therapeutic potential of post-traumatic osteoarthritis.
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自噬在创伤后骨关节炎的发病机制和治疗潜力中的作用
DOI：
10.1093/burnst/tkac060
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发表时间：
2023
期刊：
影响因子：
5.3
通讯作者：
Ni, Zhenhong
中科院分区：
文献类型：
--
作者：
Gong, Yunquan;Li, Song;Wu, Jinghui;Zhang, Tongyi;Fang, Shunzheng;Feng, Daibo;Luo, Xiaoqing;Yuan, Jing;Wu, Yaran;Yan, Xiaojing;Zhang, Yan;Zhu, Jun;Wu, Jiangyi;Lian, Jiqin;Xiang, Wei;Ni, Zhenhong
自噬作为细胞内稳态的一种基本机制，通常参与多种疾病的发生和发展。骨关节炎（OA）是最常见的肌肉骨骼疾病，常导致患者疼痛、残疾和经济损失。创伤后骨关节炎（PTOA）是OA的一个亚型，占OA总体负担的12%以上。PTOA通常由关节损伤引起，包括前交叉韧带断裂、半月板撕裂和关节内骨折。尽管已经开发了多种方法来治疗急性关节损伤，但目前的措施在有效降低PTOA的发病率和延缓其进展方面成效有限。因此，PTOA的发病机制和干预策略需要进一步研究。在过去十年中，自噬在PTOA中的作用和机制在该领域引起了极大的关注。研究表明，自噬能够维持软骨细胞的内稳态，降低关节炎症水平，防止软骨细胞死亡和基质降解，从而改善关节症状并延缓PTOA的进展。此外，许多针对PTOA的策略已被发现可促进自噬。在这篇综述中，我们总结了自噬在PTOA中的作用和机制，以及目前依赖自噬调节的PTOA治疗策略，这可能对未来的PTOA患者有益。
Abstract Autophagy, as a fundamental mechanism for cellular homeostasis, is generally involved in the occurrence and progression of various diseases. Osteoarthritis (OA) is the most common musculoskeletal disease that often leads to pain, disability and economic loss in patients. Post-traumatic OA (PTOA) is a subtype of OA, accounting for >12% of the overall burden of OA. PTOA is often caused by joint injuries including anterior cruciate ligament rupture, meniscus tear and intra-articular fracture. Although a variety of methods have been developed to treat acute joint injury, the current measures have limited success in effectively reducing the incidence and delaying the progression of PTOA. Therefore, the pathogenesis and intervention strategy of PTOA need further study. In the past decade, the roles and mechanisms of autophagy in PTOA have aroused great interest in the field. It was revealed that autophagy could maintain the homeostasis of chondrocytes, reduce joint inflammatory level, prevent chondrocyte death and matrix degradation, which accordingly improved joint symptoms and delayed the progression of PTOA. Moreover, many strategies that target PTOA have been revealed to promote autophagy. In this review, we summarize the roles and mechanisms of autophagy in PTOA and the current strategies for PTOA treatment that depend on autophagy regulation, which may be beneficial for PTOA patients in the future.
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健康衰老和疾病中的自噬。
DOI：
10.1038/s43587-021-00098-4
发表时间：
2021-08
期刊：
Nature aging
影响因子：
--
作者：
Aman Y;Schmauck-Medina T;Hansen M;Morimoto RI;Simon AK;Bjedov I;Palikaras K;Simonsen A;Johansen T;Tavernarakis N;Rubinsztein DC;Partridge L;Kroemer G;Labbadia J;Fang EF
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Fang EF
影响因子：
5.6
作者：
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通讯作者：
Wang CZ
DOI：
10.1002/art.40104
发表时间：
2017-07
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Alvarez-Garcia O;Matsuzaki T;Olmer M;Plate L;Kelly JW;Lotz MK
通讯作者：
Lotz MK
影响因子：
8.2
作者：
Dong, Jian;Zhang, Kai-Jia;Jiang, Qing
通讯作者：
Jiang, Qing
影响因子：
27.4
作者：
Caramés B;Hasegawa A;Taniguchi N;Miyaki S;Blanco FJ;Lotz M
通讯作者：
Lotz M