Autophagy in healthy aging and disease.
Autophagy in healthy aging and disease.
复制标题
健康衰老和疾病中的自噬。
DOI：
10.1038/s43587-021-00098-4
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发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Fang EF
中科院分区：
文献类型：
--
作者：
Aman Y;Schmauck-Medina T;Hansen M;Morimoto RI;Simon AK;Bjedov I;Palikaras K;Simonsen A;Johansen T;Tavernarakis N;Rubinsztein DC;Partridge L;Kroemer G;Labbadia J;Fang EF
自噬是一种基本的细胞过程，其通过溶酶体介导的降解来消除分子和亚细胞元件，包括核酸、蛋白质、脂质和细胞器，以促进稳态、分化、发育和存活。虽然自噬与健康密切相关，但自噬、衰老和疾病之间的复杂关系仍不清楚。这篇综述研究了自噬的几个新特征，并假设它们如何与衰老以及疾病的发展和进展有关。此外，我们讨论了目前的临床前证据，认为使用自噬调节剂作为抑制剂的年龄相关的病理，如神经退行性疾病。最后，我们强调了关键问题，并提出了新的研究途径，可能会揭示自噬和衰老标志之间的新联系。了解自噬与跨生物体年龄相关病理风险之间的精确相互作用，最终将促进促进长期健康的临床应用的发展。
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.
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7.3
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