Role of the Heart in Lactate Shuttling.
Role of the Heart in Lactate Shuttling.
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DOI：
10.3389/fnut.2021.663560
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发表时间：
2021
影响因子：
5
通讯作者：
Brooks GA
中科院分区：
文献类型：
--
作者：
Brooks GA
经过近世纪的误解，现在是时候认识到乳酸穿梭是能量通量和代谢调节的重要特征，涉及体内一系列复杂的代谢、神经内分泌、心血管和心脏事件。细胞-细胞和细胞内乳酸盐在心脏中以及心脏和其他组织之间穿梭，实现了能量底物产生和分布以及在完全有氧条件下细胞信号传导的基本目的。乳酸穿梭的认识首先出现在体育锻炼的研究中，其中驱动（生产者）和接受（消费者）细胞和组织的作用是显而易见的。细胞间乳酸穿梭的一个有力例子是工作肢体骨骼肌和心脏之间以乳酸形式交换碳水化合物能量。质量交换代表了质量守恒，需要神经内分泌、自动调节和心血管系统的整合。现在，随着对心动周期对心肌血流影响的更深入研究和认识，人们认识到代谢通量必须适应其发生的器官内的压力-流量现实。因此，心脏内乳酸穿梭的存在被假定为解释心脏力学和代谢是如何同步的。具体地，在收缩期的等渗阶段期间血流的中断由糖酵解支持，并且随后在舒张期期间血流的返回允许通过氧化代谢维持恢复。
After almost a century of misunderstanding, it is time to appreciate that lactate shuttling is an important feature of energy flux and metabolic regulation that involves a complex series of metabolic, neuroendocrine, cardiovascular, and cardiac events in vivo. Cell–cell and intracellular lactate shuttles in the heart and between the heart and other tissues fulfill essential purposes of energy substrate production and distribution as well as cell signaling under fully aerobic conditions. Recognition of lactate shuttling came first in studies of physical exercise where the roles of driver (producer) and recipient (consumer) cells and tissues were obvious. One powerful example of cell–cell lactate shuttling was the exchange of carbohydrate energy in the form of lactate between working limb skeletal muscle and the heart. The exchange of mass represented a conservation of mass that required the integration of neuroendocrine, autoregulatory, and cardiovascular systems. Now, with greater scrutiny and recognition of the effect of the cardiac cycle on myocardial blood flow, there brings an appreciation that metabolic fluxes must accommodate to pressure-flow realities within an organ in which they occur. Therefore, the presence of an intra-cardiac lactate shuttle is posited to explain how cardiac mechanics and metabolism are synchronized. Specifically, interruption of blood flow during the isotonic phase of systole is supported by glycolysis and subsequent return of blood flow during diastole allows for recovery sustained by oxidative metabolism.
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DOI：
10.1152/ajpendo.1999.277.1.e81
发表时间：
1999-07-01
影响因子：
5.1
作者：
Bergman, BC;Butterfield, GE;Brooks, GA
通讯作者：
Brooks, GA
DOI：
10.1152/ajpendo.1999.276.1.e106
发表时间：
1999-01-01
影响因子：
5.1
作者：
Bergman, BC;Butterfield, GE;Brooks, GA
通讯作者：
Brooks, GA
影响因子：
5.5
作者：
Bergman, Bryan C.;Tsvetkova, Tatiana;Wolfel, Eugene E.
通讯作者：
Wolfel, Eugene E.
DOI：
10.1152/ajpregu.1998.275.4.r1192
发表时间：
1998-10-01
影响因子：
2.8
作者：
Brooks, GA;Wolfel, EE;Reeves, JT
通讯作者：
Reeves, JT
影响因子：
5.9
作者：
BING, RJ;SIEGEL, A;EDWARDS, S
通讯作者：
EDWARDS, S