A new branch connecting thermogenesis and diabetes.
A new branch connecting thermogenesis and diabetes.
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DOI:
10.1038/s42255-019-0112-1
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发表时间:
2019-09
影响因子:
20.8
通讯作者:
Wang, Yibin
中科院分区:
文献类型:
--
作者:
Sun, Haipeng;Wang, Yibin
Systemic accumulation of branched-chain amino acids (BCAAs) is a major metabolic hallmark and contributor to insulin resistance associated with obesity. A recent report identifies SLC25A44 as the BCAA transporter in mitochondrial membranes and shows that BCAA catabolism in brown adipose tissue significantly affects thermogenic activity, systemic BCAA clearance, energy expenditure and overall metabolic health.
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