Multiple Sclerosis: Microglia, Monocytes, and Macrophage-Mediated Demyelination.
Multiple Sclerosis: Microglia, Monocytes, and Macrophage-Mediated Demyelination.
复制标题
DOI：
10.1093/jnen/nlab083
复制
发表时间：
2021-10-26
影响因子：
3.2
通讯作者：
Parratt JDE
中科院分区：
文献类型：
--
作者：
Prineas JW;Parratt JDE
本研究探讨了小胶质细胞和单核细胞在早期多发性硬化（MS）患者髓鞘破坏中的作用。研究了22例病例; 10例病例的临床持续时间<9周。鉴定了20种髓样细胞亚型或类别，包括2种先前不知道在脱髓鞘疾病中发生的细胞类型。在斑块和血管周围和软膜下组织中开始髓鞘分解发生在浸润性单核细胞的立即存在下，并受到IgG阳性Fc受体携带早期吞噬细胞与异常髓鞘相互作用的同质群体的影响。少突胶质细胞凋亡观察到在完整的有髓组织接壤地区的活动性脱髓鞘。在MS急性病例和患有视神经肌萎缩变异和单核细胞极度全身募集的患者中，大脑皮质中的Captain被大量单核细胞堵塞是常见的。在一名患有进行性疾病的MS患者中，在大脑皮层中存在以被单核细胞堵塞的MHC-II阳性毛细血管为中心的小胶质细胞结节。这构成了MS中新的灰质病变。
This study examined the roles of microglia and monocytes in myelin destruction in patients with early multiple sclerosis (MS). Twenty-two cases were studied; the clinical duration was <9 weeks in 10 cases. Twenty myeloid cell subtypes or categories were identified including 2 cell types not known previously to occur in demyelinating diseases. Commencing myelin breakdown in plaques and in perivascular and subpial tissues occurred in the immediate presence of infiltrating monocytes and was effected by a homogeneous population of IgG-positive Fc receptor-bearing early phagocytes interacting with abnormal myelin. Oligodendrocyte apoptosis was observed in intact myelinated tissue bordering areas of active demyelination. Capillaries in the cerebral cortex plugged by large numbers of monocytes were common in acute cases of MS and in a patient with a neuromyelitis optica variant and extreme systemic recruitment of monocytes. In an MS patient with progressive disease, microglial nodules centered on MHC-II-positive capillaries plugged by monocytes were present in the cerebral cortex. This constitutes a new gray matter lesion in MS.
登录
查看更多内容
DOI：
10.1111/bpa.12813
发表时间：
2020-05
期刊：
Brain pathology (Zurich, Switzerland)
影响因子：
--
作者：
Junker A;Wozniak J;Voigt D;Scheidt U;Antel J;Wegner C;Brück W;Stadelmann C
通讯作者：
Stadelmann C
影响因子：
11.2
作者：
BRUCK, W;SCHMIED, M;LASSMANN, H
通讯作者：
LASSMANN, H
影响因子：
11.2
作者：
Breij, Esther C. W.;Brink, Bianca P.;Boe, Lars
通讯作者：
Boe, Lars
影响因子：
14.5
作者：
Bien, Christian G.;Vincent, Angela;Bauer, Jan
通讯作者：
Bauer, Jan
影响因子：
14.5
作者：
Hosp, Jonas A.;Dressing, Andrea;Meyer, Philipp T.
通讯作者：
Meyer, Philipp T.