Does Malaria Cause Diarrhoea? A Systematic Review.
Does Malaria Cause Diarrhoea? A Systematic Review.
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DOI：
10.3389/fmed.2020.589379
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发表时间：
2020
影响因子：
3.9
通讯作者：
Mooney JP
中科院分区：
文献类型：
--
作者：
Sey ICM;Ehimiyein AM;Bottomley C;Riley EM;Mooney JP
疟疾是一种全身性发热性疾病，可发展为虚脱、呼吸窘迫、脑病、贫血和死亡。疟疾也是侵袭性细菌疾病的一个既定风险因素，在大多数情况下，由侵袭性肠道病原体，特别是非伤寒沙门氏菌（NTS）引起。虽然在动物模型中，各种疟疾相关的病理学与NTS菌血症的风险有关，包括肠道生态失调和肠道稳态丧失，但缺乏临床证据。作为收集此类证据的第一步，我们对报告疟疾病例中腹泻流行率的临床和流行病学研究进行了系统审查，反之亦然。数据库检索“疟原虫”和“腹泻”识别出1，771篇文章;检索“疟原虫”和“胃肠炎”识别出另外215篇文章。经过审查，66篇文章指定了检索词之间的关联，主要但不完全涉及恶性疟原虫感染。总体而言，1.6%至44%的急性疟疾感染患者报告了腹泻症状（7，267人中的812人，11%），而5%至42%的腹泻患者有潜在的疟疾寄生虫感染（2，937人中的749人，26%）。然而，由于估计范围广泛，缺乏有目的的病例对照或纵向研究，以及腹泻的定义不同或定义不明确，文献提供的证据有限，无法得出任何明确的结论。因此，疟疾与胃肠道紊乱之间的关系仍不清楚。需要进行精心设计的病例对照研究和前瞻性纵向研究，以自信地评估疟疾寄生虫感染肠道表现的患病率和意义。
Malaria is a systemic febrile disease that may progress to prostration, respiratory distress, encephalopathy, anemia, and death. Malaria is also an established risk factor for invasive bacterial disease caused, in the majority of cases, by invasive enteropathogens and in particular by non-Typhoidal Salmonella (NTS). Whilst various malaria-related pathologies have been implicated in the risk of NTS bacteraemia in animal models, including intestinal dysbiosis and loss of gut homeostasis, clinical evidence is lacking. As a first step in gathering such evidence, we conducted a systematic review of clinical and epidemiological studies reporting the prevalence of diarrhoea among malaria cases and vice versa. Database searches for “plasmodium” and “diarrhoea” identified 1,771 articles; a search for “plasmodium” and “gastroenteritis” identified a further 215 articles. After review, 66 articles specified an association between the search terms and referred primarily, but not exclusively, to Plasmodium falciparum infections. Overall, between 1.6 and 44% of patients with acute malaria infection reported symptoms of diarrhoea (812 of 7,267 individuals, 11%) whereas 5–42% of patients presenting to hospital with diarrhoea had an underlying malaria parasite infection (totaling 749 of 2,937 individuals, 26%). However, given the broad range of estimates, a paucity of purposeful case control or longitudinal studies, and varied or poorly specified definitions of diarrhoea, the literature provides limited evidence to draw any firm conclusions. The relationship between malaria and gastrointestinal disturbance thus remains unclear. Carefully designed case-control studies and prospective longitudinal studies are required to confidently assess the prevalence and significance of intestinal manifestations of malaria parasite infection.
影响因子：
3.7
作者：
He D;Zhang Y;Liu X;Guo S;Zhao D;Zhu Y;Li H;Kong L
通讯作者：
Kong L
影响因子：
3.8
作者：
Tao ZY;Fang Q;Liu X;Culleton R;Tao L;Xia H;Gao Q
通讯作者：
Gao Q