Congenital malaria in China.
Congenital malaria in China.
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DOI：
10.1371/journal.pntd.0002622
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发表时间：
2014-03
影响因子：
3.8
通讯作者：
Gao Q
中科院分区：
文献类型：
--
作者：
Tao ZY;Fang Q;Liu X;Culleton R;Tao L;Xia H;Gao Q
先天性疟疾是指婴儿在出生前或出生期间直接从母亲那里感染疟疾寄生虫，这是一种潜在的危及生命的疾病，在疟疾流行地区发病率相对较低。在恶性疟原虫流行的撒哈拉以南非洲，它被认为是一个严重的问题，最近的数据表明，在那里，它比以前认为的更常见。在疟疾传播率高的这些地区，新生儿可以通过转移针对寄生虫的母体抗体而免受先天性疟疾引起的疾病的影响。然而，在低间日疟流行地区，对间日疟的免疫力较低；因此，先天性间日疟有可能对新生儿健康构成更严重的威胁。疟疾此前是中国的主要寄生虫病，中文的先天性疟疾病例报告为了解先天性疟疾对新生儿健康构成的风险提供了宝贵的信息。由于记录中国先天疟疾病例的文献大多是用中文撰写的，因此全球疟疾研究界很难获得，因此我们对有关这一主题的中文文献进行了广泛的回顾。在这里，我们回顾了来自三个主要的可搜索中文期刊数据库的先天性疟疾病例，集中在1915年到2011年的数据上。经过广泛筛查，共确认104例先天性疟疾病例。这些病例主要分布在中国的东部、中部和南部地区，以及中国西南的低洼地区。优势种为间日疟原虫(92.50%)，反映了中国地区疟疾寄生虫的种类分布。主要临床表现为发热，其他临床表现为贫血、黄胆、面色苍白、腹泻、呕吐和全身无力。除两例外，所有患者均用氯喹、奎宁、蒿甲醚和青蒿琥酯等抗疟疾药物治愈。先天性疟疾的症状在不同病例之间差异很大，因此很难明确和早期诊断。我们建议对有疟疾病史的母亲所生的新生儿进行积极监测可能是必要的。
Congenital malaria, in which infants are directly infected with malaria parasites from their mother prior to or during birth, is a potentially life-threatening condition that occurs at relatively low rates in malaria-endemic regions. It is recognized as a serious problem in Plasmodium falciparum–endemic sub-Saharan Africa, where recent data suggests that it is more common than previously believed. In such regions where malaria transmission is high, neonates may be protected from disease caused by congenital malaria through the transfer of maternal antibodies against the parasite. However, in low P. vivax–endemic regions, immunity to vivax malaria is low; thus, there is the likelihood that congenital vivax malaria poses a more significant threat to newborn health. Malaria had previously been a major parasitic disease in China, and congenital malaria case reports in Chinese offer valuable information for understanding the risks posed by congenital malaria to neonatal health. As most of the literature documenting congenital malaria cases in China are written in Chinese and therefore are not easily accessible to the global malaria research community, we have undertaken an extensive review of the Chinese literature on this subject. Here, we reviewed congenital malaria cases from three major searchable Chinese journal databases, concentrating on data from 1915 through 2011. Following extensive screening, a total of 104 cases of congenital malaria were identified. These cases were distributed mainly in the eastern, central, and southern regions of China, as well as in the low-lying region of southwest China. The dominant species was P. vivax (92.50%), reflecting the malaria parasite species distribution in China. The leading clinical presentation was fever, and other clinical presentations were anaemia, jaundice, paleness, diarrhoea, vomiting, and general weakness. With the exception of two cases, all patients were cured with antimalarial drugs such as chloroquine, quinine, artemether, and artesunate. The symptoms of congenital malaria vary significantly between cases, so clear and early diagnosis is difficult. We suggest that active surveillance might be necessary for neonates born to mothers with a history of malaria.
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作者：
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