Polymorphism at the apical membrane antigen 1 locus reflects the world population history of Plasmodium vivax.
Polymorphism at the apical membrane antigen 1 locus reflects the world population history of Plasmodium vivax.
复制标题
DOI：
10.1186/1471-2148-8-123
复制
发表时间：
2008-04-29
影响因子：
3.4
通讯作者：
Braga, Erika M.
中科院分区：
文献类型：
--
作者：
Grynberg, Priscila;Fontes, Cor Jesus F.;Hughes, Austin L.;Braga, Erika M.
在疟疾寄生虫（疟原虫属）中，ama-1是编码顶端膜蛋白-1的高度多态性位点，并且有证据表明该位点的多态性被选择性地维持。我们测试的假设，在ama-1基因座的多态性反映了间日疟原虫，这被认为是起源于东南亚和广泛的地理分布的人口历史。特别是，我们测试了在欧洲征服和非洲奴隶贸易以及随后的人口扩张期间将P. vivax引入新世界的签名。一百零五个ama-1序列生成和分析的样本来自六个不同的巴西国家和旧世界的数据库序列进行比较。间日疟原虫的旧世界种群显示出大量的种群亚结构证据，在同义和非同义位点的地方之间具有较高的序列差异，而巴西分离株显示出减少的多样性和很少的种群亚结构。这些结果表明，间日疟原虫AMA-1的遗传多样性反映了种群历史，种群子结构特征为历史悠久的旧世界种群，而巴西种群则显示出多样性丧失和近期种群扩张的证据。本文报道的核苷酸序列数据可在GenBank™数据库中以登录号EF 031154-EF 031216和EF 057446-EF 057487获得
In malaria parasites (genus Plasmodium), ama-1 is a highly polymorphic locus encoding the Apical Membrane Protein-1, and there is evidence that the polymorphism at this locus is selectively maintained. We tested the hypothesis that polymorphism at the ama-1 locus reflects population history in Plasmodium vivax, which is believed to have originated in Southeast Asia and is widely geographically distributed. In particular, we tested for a signature of the introduction of P. vivax into the New World at the time of the European conquest and African slave trade and subsequent population expansion. One hundred and five ama-1 sequences were generated and analyzed from samples from six different Brazilian states and compared with database sequences from the Old World. Old World populations of P. vivax showed substantial evidence of population substructure, with high sequence divergence among localities at both synonymous and nonsynonymous sites, while Brazilian isolates showed reduced diversity and little population substructure. These results show that genetic diversity in P. vivax AMA-1 reflects population history, with population substructure characterizing long-established Old World populations, whereas Brazilian populations show evidence of loss of diversity and recent population expansion. Nucleotide sequence data reported is this paper are available in the GenBank™ database under the accession numbers EF031154 – EF031216 and EF057446 – EF057487
登录
查看更多内容
影响因子：
2.1
作者：
CREWTHER, PE;CULVENOR, JG;ANDERS, RF
通讯作者：
ANDERS, RF
影响因子：
10.7
作者：
Gunasekera, Anusha M.;Wickramarachchi, Thilan;Wirth, Dyann F.
通讯作者：
Wirth, Dyann F.
影响因子：
10.7
作者：
Imwong, M;Sudimack, D;Anderson, TJC
通讯作者：
Anderson, TJC
影响因子：
10.7
作者：
Jongwutiwes, S;Putaporntip, C;Hughes, AL
通讯作者：
Hughes, AL
影响因子：
3.6
作者：
Healer, J;Murphy, V;Batchelor, A
通讯作者：
Batchelor, A