Novel Approaches in the Inhibition of IgE-Induced Mast Cell Reactivity in Food Allergy.
Novel Approaches in the Inhibition of IgE-Induced Mast Cell Reactivity in Food Allergy.
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抑制食物过敏中IgE诱导的肥大细胞反应的新方法。
DOI：
10.3389/fimmu.2021.613461
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发表时间：
2021
影响因子：
7.3
通讯作者：
Bulfone-Paus S
中科院分区：
文献类型：
--
作者：
Tontini C;Bulfone-Paus S
过敏是一种依赖ige的i型超敏反应，可导致危及生命的全身症状，如过敏反应。在过敏反应的发病机制中，常见的上游事件是过敏原与特异性IgE结合，诱导高亲和的FcεRI在肥大细胞上交联，触发细胞脱颗粒，释放具有炎症活性的组胺、蛋白酶、脂质介质、细胞因子和趋化因子。许多抑制肥大细胞活化的新疗法正在开发中，用于治疗严重过敏。除了抗IgE治疗和过敏原特异性免疫治疗外，针对几种关键Th2/报警蛋白细胞因子（如IL-4Rα， IL-33， TSLP）的单克隆抗体，过敏原特异性IgE的活性修饰（即抑制性化合物，单克隆抗体，去唾液化），肥大细胞上的抑制性受体和过敏原特异性佐剂疫苗的参与，是抑制肥大细胞介质在过敏原暴露时不受控制的释放的新的有希望的选择。在这篇综述中，我们批判性地讨论了针对肥大细胞限制过敏反应的新方法及其涉及的免疫学机制，特别对食物过敏治疗感兴趣。
Allergy is an IgE-dependent type-I hypersensitivity reaction that can lead to life-threatening systemic symptoms such as anaphylaxis. In the pathogenesis of the allergic response, the common upstream event is the binding of allergens to specific IgE, inducing cross-linking of the high-affinity FcεRI on mast cells, triggering cellular degranulation and the release of histamine, proteases, lipids mediators, cytokines and chemokines with inflammatory activity. A number of novel therapeutic options to curb mast cell activation are in the pipeline for the treatment of severe allergies. In addition to anti-IgE therapy and allergen-specific immunotherapy, monoclonal antibodies targeted against several key Th2/alarmin cytokines (i.e. IL-4Rα, IL-33, TSLP), active modification of allergen-specific IgE (i.e. inhibitory compounds, monoclonal antibodies, de-sialylation), engagement of inhibitory receptors on mast cells and allergen-specific adjuvant vaccines, are new promising options to inhibit the uncontrolled release of mast cell mediators upon allergen exposure. In this review, we critically discuss the novel approaches targeting mast cells limiting allergic responses and the immunological mechanisms involved, with special interest on food allergy treatment.
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DOI：
10.1084/jem.20062211
发表时间：
2007-02-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
Delespesse G
影响因子：
14.2
作者：
Bruton, Kelly;Spill, Paul;Jordana, Manel
通讯作者：
Jordana, Manel
DOI：
10.1186/s13223-017-0223-8
发表时间：
2017
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
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作者：
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通讯作者：
Nadeau KC
DOI：
10.1172/jci87492
发表时间：
2016-11-01
期刊：
The Journal of clinical investigation
影响因子：
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作者：
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通讯作者：
Abraham SN
影响因子：
4.4
作者：
Bachelet, Ido;Munitz, Ariel;Levi-Schaffer, Francesca
通讯作者：
Levi-Schaffer, Francesca