Differential Effects of Tight and Loose 2‐Hour Restraint Stress on Extracellular Concentrations of Dopamine in Nucleus Accumbens and Anteromedial Frontal Cortex
Differential Effects of Tight and Loose 2‐Hour Restraint Stress on Extracellular Concentrations of Dopamine in Nucleus Accumbens and Anteromedial Frontal Cortex
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紧和松的 2 小时约束压力对伏核和前内侧额叶皮层细胞外多巴胺浓度的不同影响
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
M. Kurachi
中科院分区：
文献类型：
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作者：
K. Kurata;Y. Tanii;R. Shibata;M. Kurachi
摘要：通过微透析方法，在 2 小时松紧约束应激期间，检查了伏隔核 (NAS) 和前内侧额叶皮层 (AMFCx) 细胞外多巴胺 (DA) 浓度的变化。宽松的约束导致 AMFCx 和 NAS 中的 DA 释放分别显着增加 100% 和 30%，并且尽管持续存在压力，增加的 DA 水平仍恢复到对照值。严格的约束导致 AMFCx 在应激过程中几乎恒定地增加 100-130%，而 NAS 则减少 30%。在停止宽松但不严格的约束后不久，在两个区域都观察到 DA 释放的短暂增加。
Abstract: Changes in the extracellular dopamine (DA) concentrations were examined in the nucleus accumbens (NAS) and anteromedial frontal cortex (AMFCx) during either 2‐hr loose or tight restraint stress by means of a microdialysis method. Loose restraint induced significant 100% and 30% increases in DA release in the AMFCx and NAS, respectively, and the increased DA levels returned to the control values despite continued stress. Tight restraint induced an almost constant 100–130% increase during stressing in the AMFCx and a 30% reduction in the NAS. Transient increases in DA release were observed in both regions soon after the cessation of loose, but not tight, restraint.
影响因子：
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作者：
A. Deutch;R. Roth
通讯作者：
A. Deutch;R. Roth
影响因子：
56.9
作者：
FREED, CR;YAMAMOTO, BK
通讯作者：
YAMAMOTO, BK