Type I interferon signaling, regulation and gene stimulation in chronic virus infection.
Type I interferon signaling, regulation and gene stimulation in chronic virus infection.
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DOI：
10.1016/j.smim.2019.05.001
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发表时间：
2019-06
影响因子：
7.8
通讯作者：
Brooks DG
中科院分区：
文献类型：
--
作者：
Lukhele S;Boukhaled GM;Brooks DG
I型干扰素（IFN-1）在病毒感染期间介导许多免疫相互作用，从建立抗病毒状态到调用和调节消除感染的先天性和适应性免疫细胞。虽然持续的IFN-I信号传导在急性和慢性感染期间限制病毒复制方面发挥着关键作用，但持续的IFN-I信号传导也会导致慢性免疫激活、炎症，从而导致免疫衰竭和功能障碍。因此，对慢性IFN-I信号传导的期望效应和有害效应之间的平衡的理解将为我们对慢性病毒感染以及其他慢性疾病（包括癌症）的基于IFN的疗法的探索提供信息。因此，参与IFN-1信号传导的诱导、增殖和调节的因素，从细胞内病毒核苷酸的初始感测到调节下游信号传导因子和产生的IFN-刺激基因（ISG），已经受到显著的研究关注。这篇综述总结了最近关于慢性感染中IFN-Ⅰ信号传导的工作，并提供了正在考虑对抗此类感染的治疗方法的最新进展。
Type I Interferons (IFN-I) mediate numerous immune interactions during viral infections, from the establishment of an antiviral state to invoking and regulating innate and adaptive immune cells that eliminate infection. While continuous IFN-I signaling plays critical roles in limiting virus replication during both acute and chronic infections, sustained IFN-I signaling also leads to chronic immune activation, inflammation and, consequently, immune exhaustion and dysfunction. Thus, an understanding of the balance between the desirable and deleterious effects of chronic IFN-I signaling will inform our quest for IFN-based therapies for chronic viral infections as well as other chronic diseases, including cancer. As such the factors involved in induction, propagation and regulation of IFN-I signaling, from the initial sensing of viral nucleotides within the cell to regulatory downstream signaling factors and resulting IFN-stimulated genes (ISGs) have received significant research attention. This review summarizes recent work on IFN-I signaling in chronic infections, and provides an update on therapeutic approaches being considered to counter such infections.
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影响因子：
64.5
作者：
Benci JL;Xu B;Qiu Y;Wu TJ;Dada H;Twyman-Saint Victor C;Cucolo L;Lee DSM;Pauken KE;Huang AC;Gangadhar TC;Amaravadi RK;Schuchter LM;Feldman MD;Ishwaran H;Vonderheide RH;Maity A;Wherry EJ;Minn AJ
通讯作者：
Minn AJ
影响因子：
4.3
作者：
Sy BT;Hoan NX;Tong HV;Meyer CG;Toan NL;Song LH;Bock CT;Velavan TP
通讯作者：
Velavan TP
DOI：
10.1073/pnas.0903487106
发表时间：
2009-06-09
影响因子：
11.1
作者：
Cheon, HyeonJoo;Stark, George R.
通讯作者：
Stark, George R.
影响因子：
11.4
作者：
Cheon, HyeonJoo;Holvey-Bates, Elise G.;Schoggins, John W.;Forster, Samuel;Hertzog, Paul;Imanaka, Naoko;Rice, Charles M.;Jackson, Mark W.;Junk, Damian J.;Stark, George R.
通讯作者：
Stark, George R.
影响因子：
32.4
作者：
Chang, Yu-Han;Wang, Kuan Chung;Watts, Tania H.
通讯作者：
Watts, Tania H.