Age-related topographic map of magnetic resonance diffusion metrics in neonatal brains.
Age-related topographic map of magnetic resonance diffusion metrics in neonatal brains.
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DOI：
10.1002/hbm.25956
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发表时间：
2022-10-01
影响因子：
4.8
通讯作者：
Payabvash, Seyedmehdi
中科院分区：
文献类型：
--
作者：
Bobba, Pratheek S.;Weber, Clara F.;Mak, Adrian;Mozayan, Ali;Malhotra, Ajay;Sheth, Kevin N.;Taylor, Sarah N.;Vossough, Arastoo;Grant, Patricia Ellen;Scheinost, Dustin;Constable, Robert Todd;Ment, Laura R.;Payabvash, Seyedmehdi
接近足月年龄的脑实质加速成熟导致新生儿大脑的弥散加权成像（DWI）和弥散张量成像（DTI）指标快速变化，这可能使这些扫描的评价和解释复杂化。在这项研究中，我们描述了新生儿大脑中扩散指标与年龄相关的演变的地形图。我们纳入了565名在0 ~ 3个月之间接受MRI检查的新生儿，无结构或信号异常，其中162名接受了DTI扫描。我们分析了整个大脑的表观扩散系数（ADC）值和沿着白色（WM）束的DTI指标（各向异性分数[FA]和平均扩散率[MD]）的年龄相关变化。计算5 mm立方体素的ADC、FA和MD值的变化率。随着胎龄（GA）的增加，新生儿脑内ADC和MD值显著降低，FA值增加，皮质下WM、皮质脊髓束、小脑WM和小脑蚓部的时间比率最高。出生时GA对凸面皮质和胼胝体的ADC值以及胼胝体的FA/MD值有显著影响，校正扫描时GA后。我们开发了在线交互式地图集，描述了ADC（年龄34-46周）和FA/MD（35-41周）的年龄特异性标准值。我们的研究结果表明，在新生儿年龄的前几周，大脑/小脑WM和小脑蚓部的扩散率指标迅速下降，可能归因于髓鞘形成。此外，早产和出生时低GA可能导致胼胝体髓鞘形成和大脑皮质细胞结构的持续延迟。在这项研究中，我们描述了新生儿大脑中扩散指标与年龄相关的演变的地形图。此外，我们开发了在线交互式图谱，描述了表观扩散系数、分数各向异性和平均扩散率的年龄特异性标准值。
Accelerated maturation of brain parenchyma close to term‐equivalent age leads to rapid changes in diffusion‐weighted imaging (DWI) and diffusion tensor imaging (DTI) metrics of neonatal brains, which can complicate the evaluation and interpretation of these scans. In this study, we characterized the topography of age‐related evolution of diffusion metrics in neonatal brains. We included 565 neonates who had MRI between 0 and 3 months of age, with no structural or signal abnormality—including 162 who had DTI scans. We analyzed the age‐related changes of apparent diffusion coefficient (ADC) values throughout brain and DTI metrics (fractional anisotropy [FA] and mean diffusivity [MD]) along white matter (WM) tracts. Rate of change in ADC, FA, and MD values across 5 mm cubic voxels was calculated. There was significant reduction of ADC and MD values and increase of FA with increasing gestational age (GA) throughout neonates' brain, with the highest temporal rates in subcortical WM, corticospinal tract, cerebellar WM, and vermis. GA at birth had significant effect on ADC values in convexity cortex and corpus callosum as well as FA/MD values in corpus callosum, after correcting for GA at scan. We developed online interactive atlases depicting age‐specific normative values of ADC (ages 34–46 weeks), and FA/MD (35–41 weeks). Our results show a rapid decrease in diffusivity metrics of cerebral/cerebellar WM and vermis in the first few weeks of neonatal age, likely attributable to myelination. In addition, prematurity and low GA at birth may result in lasting delay in corpus callosum myelination and cerebral cortex cellularity. In this study, we characterized the topography of age‐related evolution of diffusion metrics in neonatal brains. In addition, we developed online interactive atlases depicting age‐specific normative values of apparent diffusion coefficient, fractional anisotropy, and mean diffusivity.
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DOI：
10.1016/j.ijdevneu.2013.06.004
发表时间：
2013-11
期刊：
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
影响因子：
--
作者：
Oishi K;Faria AV;Yoshida S;Chang L;Mori S
通讯作者：
Mori S
影响因子：
5
作者：
McGraw, P;Liang, LX;Provenzale, JM
通讯作者：
Provenzale, JM
影响因子：
3.5
作者：
Liauw, L.;van Wezel-Meijler, G.;van der Grond, J.
通讯作者：
van der Grond, J.
影响因子：
2.9
作者：
Lemmon ME;Wagner MW;Bosemani T;Carson KA;Northington FJ;Huisman TAGM;Poretti A
通讯作者：
Poretti A
影响因子：
5.7
作者：
Feng L;Li H;Oishi K;Mishra V;Song L;Peng Q;Ouyang M;Wang J;Slinger M;Jeon T;Lee L;Heyne R;Chalak L;Peng Y;Liu S;Huang H
通讯作者：
Huang H