Age-specific gray and white matter DTI atlas for human brain at 33, 36 and 39 postmenstrual weeks.
Age-specific gray and white matter DTI atlas for human brain at 33, 36 and 39 postmenstrual weeks.
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DOI：
10.1016/j.neuroimage.2018.06.069
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发表时间：
2019-01-15
期刊：
影响因子：
5.7
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Feng L;Li H;Oishi K;Mishra V;Song L;Peng Q;Ouyang M;Wang J;Slinger M;Jeon T;Lee L;Heyne R;Chalak L;Peng Y;Liu S;Huang H
在妊娠的第三个三个月，人类大脑的结构发生了戏剧性的变化，这是神经回路形成的基础。近年来，早产儿的存活率显著提高。33周或36周(PMW)的早产儿脑与40 PMW(足月)的早产儿脑的形态有很大的差异，因此有必要建立早产儿脑的年龄图谱。本研究利用84例健康早产儿和足月儿的高质量(1.5×1.5×1.6 mm~3成像分辨率)弥散张量成像(DTI)数据，建立了33、36和39PMW的早产儿和足月儿的年龄特异脑模板和图谱。特定年龄的DTI模板包括单一受试者模板、具有线性变换的总体平均模板和具有非线性变换的总体平均模板。每份特定年龄的DTI图谱包括126个主要灰质(GM)和白质(WM)结构的全面标记，特别是52个大脑皮质结构、40个大脑WM结构、22个脑干和小脑结构以及12个皮质下GM结构。33~39PMW，可见神经节突起、钩束等单个神经结构的形态变化。根据骰子比率和L1误差的测量进行的评估表明，与手动描绘的标签相比，来自年龄匹配图谱的自动标签可靠且可重现。应用这些图谱自动和有效地描绘了妊娠晚期主要西医动脉束的微结构变化。所建立的33、36和39 pmW脑的年龄特异性DTI模板和图谱不仅可以用于了解复杂但组织精确的功能和结构成熟过程，还可以用于检测早产儿脑内神经功能障碍的生物标志物，作为临床参考。
During the 3rd trimester, dramatic structural changes take place in the human brain, underlying the neural circuit formation. The survival rate of premature infants has increased significantly in recent years. The large morphological differences of the preterm brain at 33 or 36 postmenstrual weeks (PMW) from the brain at 40PMW (full term) make it necessary to establish age-specific atlases for preterm brains. In this study, with high quality (1.5×1.5×1.6mm3 imaging resolution) diffusion tensor imaging (DTI) data obtained from 84 healthy preterm and term-born neonates, we established age-specific preterm and term-born brain templates and atlases at 33, 36 and 39PMW. Age-specific DTI templates include a single-subject template, a population-averaged template with linear transformation and a population-averaged template with nonlinear transformation. Each of the age-specific DTI atlases includes comprehensive labeling of 126 major gray matter (GM) and white matter (WM) structures, specifically 52 cerebral cortical structures, 40 cerebral WM structures, 22 brainstem and cerebellar structures and 12 subcortical GM structures. From 33 to 39 PMW, dramatic morphological changes of delineated individual neural structures such as ganglionic eminence and uncinate fasciculus were revealed. The evaluation based on measurements of Dice ratio and L1 error suggested reliable and reproducible automated labels from the age-matched atlases compared to labels from manual delineation. Applying these atlases to automatically and effectively delineate microstructural changes of major WM tracts during the 3rd trimester was demonstrated. The established age-specific DTI templates and atlases of 33, 36 and 39 PMW brains may be used for not only understanding the complicated yet precisely organized functional and structural maturational processes but also detecting neural disorder biomarkers of the preterm brains as clinical references.
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影响因子：
5.7
作者：
Batalle D;Hughes EJ;Zhang H;Tournier JD;Tusor N;Aljabar P;Wali L;Alexander DC;Hajnal JV;Nosarti C;Edwards AD;Counsell SJ
通讯作者：
Counsell SJ
白质图的概率图在新生儿脑图集上具有已知相关功能：评估纵向出生和早产儿的纵向发育轨迹的应用。
影响因子：
5.7
作者：
Akazawa K;Chang L;Yamakawa R;Hayama S;Buchthal S;Alicata D;Andres T;Castillo D;Oishi K;Skranes J;Ernst T;Oishi K
通讯作者：
Oishi K
早产儿大脑连接组学分析揭示功能网络分离的早期发展
影响因子：
3.7
作者：
Cao, Miao;He, Yong;Huang, Hao
通讯作者：
Huang, Hao
DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
5.7
作者：
Huang, Hao;Zhang, Jiangyang;Mori, Susumu
通讯作者：
Mori, Susumu