Aerosol-jet printing facilitates the rapid prototyping of microfluidic devices with versatile geometries and precise channel functionalization.
Aerosol-jet printing facilitates the rapid prototyping of microfluidic devices with versatile geometries and precise channel functionalization.
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DOI：
10.1016/j.apmt.2020.100618
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发表时间：
2020-06
影响因子：
8.3
通讯作者：
Kar-Narayan S
中科院分区：
文献类型：
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作者：
Ćatić N;Wells L;Al Nahas K;Smith M;Jing Q;Keyser UF;Cama J;Kar-Narayan S
气溶胶喷射打印用于制造具有定制几何形状的微流体装置，包括台阶和斜坡。一种用于生产具有精确通道功能化的微流体装置的定制模具的快速原型制作方法。通过使用PVA使微流体通道的一部分亲水来证明功能化能力。微流体技术已成为生物学和生物医学研究的强大分析工具，其用途从单细胞表型分析到药物发现和医学诊断，并且仅需要少量样品进行测试。快速原型化新设计的能力在研究环境中是非常有益的，但是通常使用的制造技术的高成本、缓慢周转和浪费性质，特别是对于复杂的多层几何形状，严重阻碍了开发过程。此外，大多数设备中的微流体通道目前起着被动作用，通常用于引导流动。在精确的空间位置用不同的材料“功能化”通道的能力将是一系列应用的主要优点。这将涉及将功能材料直接纳入通道中，这些材料可以参与，引导或促进精确控制的微环境中的反应。在这里，我们展示了使用气溶胶喷射打印（AJP）快速生产定制模具的微流体设备具有一系列不同的几何形状和精确的“通道内”功能。我们表明，这种先进的微尺度增材制造方法可用于快速设计具有成本效益和定制的微流体设备，并能够在微流体通道内的特定位置添加功能涂层。我们证明了我们的技术的功能化能力，通过专门涂覆一部分的微流体通道与聚乙烯醇，使其亲水性。这种多功能的微流控器件原型技术将在学术和工业背景下为生物和生物医学研究提供有力的帮助。
Aerosol-jet printing is used to fabricate microfluidic devices with customised geometries, including steps and slopes. A rapid prototyping method for producing bespoke molds for microfluidic devices with precise channel functionalization. The functionalization capability is demonstrated by rendering a section of a microfluidic channel hydrophilic using PVA. Microfluidics has emerged as a powerful analytical tool for biology and biomedical research, with uses ranging from single-cell phenotyping to drug discovery and medical diagnostics, and only small sample volumes required for testing. The ability to rapidly prototype new designs is hugely beneficial in a research environment, but the high cost, slow turnaround, and wasteful nature of commonly used fabrication techniques, particularly for complex multi-layer geometries, severely impede the development process. In addition, microfluidic channels in most devices currently play a passive role and are typically used to direct flows. The ability to “functionalize” the channels with different materials in precise spatial locations would be a major advantage for a range of applications. This would involve incorporating functional materials directly within the channels that can partake in, guide or facilitate reactions in precisely controlled microenvironments. Here we demonstrate the use of Aerosol Jet Printing (AJP) to rapidly produce bespoke molds for microfluidic devices with a range of different geometries and precise “in-channel” functionalization. We show that such an advanced microscale additive manufacturing method can be used to rapidly design cost-efficient and customized microfluidic devices, with the ability to add functional coatings at specific locations within the microfluidic channels. We demonstrate the functionalization capabilities of our technique by specifically coating a section of a microfluidic channel with polyvinyl alcohol to render it hydrophilic. This versatile microfluidic device prototyping technique will be a powerful aid for biological and bio-medical research in both academic and industrial contexts.
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影响因子：
6.1
作者：
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通讯作者：
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影响因子：
41.2
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