Maize centromeres: where sequence meets epigenetics

Maize centromeres: where sequence meets epigenetics
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玉米着丝粒:序列与表观遗传学的结合

DOI:
10.1007/s11515-011-1118-6
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发表时间:
2011-04
期刊:
Frontiers of Biology
影响因子:
--
通讯作者:
Fangpu Han
Fangpu Han
中科院分区:
其他
文献类型:
--
作者:
Wenchao Yin;James Birchler;Fangpu Han

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着丝粒是一种高度有序的结构,主要由重复序列组成,这使得该区域的测序和其他分析非常困难。在有丝分裂和减数分裂中,它在染色体平等分裂成子代细胞中起着保守的作用。然而,着丝粒序列显示出显著的可塑性。在双着丝粒染色体中,其中一个着丝粒可能会失活,而下面的DNA没有变化。此外,以前不活跃的着丝粒在某些条件下可以恢复活动。此外,在广泛的物种中发现了没有着丝粒重复的新着丝粒。这一证据表明,表观遗传机制和着丝粒序列与着丝粒规范有关。
The centromere is a highly organized structure mainly composed of repeat sequences, which make this region extremely difficult for sequencing and other analyses. It plays a conserved role in equal division of chromosomes into daughter cells in both mitosis and meiosis. However, centromere sequences show notable plasticity. In a dicentric chromosome, one of the centromeres can become inactivated with the underlying DNA unchanged. Furthermore, formerly inactive centromeres can regain activity under certain conditions. In addition, neocentromeres without centromeric repeats have been found in a wide spectrum of species. This evidence indicates that epigenetic mechanisms together with centromeric sequences are associated with centromere specification.
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DOI: --
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着丝粒处的染色质组装与 DNA 复制脱钩。
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