microRNA dysregulation in prostate cancer: network analysis reveals preferential regulation of highly connected nodes.
microRNA dysregulation in prostate cancer: network analysis reveals preferential regulation of highly connected nodes.
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DOI：
10.1002/cbdv.201100386
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发表时间：
2012-05
影响因子：
2.9
通讯作者：
Zehner, Zendra E.
中科院分区：
文献类型：
--
作者：
Budd, William T.;Weaver, Danielle E.;Anderson, Joe;Zehner, Zendra E.
microRNAs （miRNAs）是一种小rna，参与许多细胞过程，包括细胞生长、分化和凋亡。mirna通过与信使RNA （mRNA）结合，在转录后调控靶基因的表达，导致翻译抑制或mRNA降解。miRNA表达失调可促进癌症的形成和发展。研究主要集中在单个mirna的功能和表达上。然而，复杂的生理过程需要包括mirna和蛋白质在内的许多分子的相互作用、调节和协调。高度连接的分子通常在细胞中起重要作用。已建立的miRNA靶点的蛋白-蛋白相互作用网络证实，这些蛋白与细胞高度相关，对细胞至关重要，影响肿瘤发生、细胞生长/增殖、细胞死亡、细胞组装和维持途径。该分析表明，mirna有助于前列腺的整体健康，它们的异常表达破坏了体内平衡。这种整合网络方法可以揭示前列腺癌中重要的mirna和蛋白质，这些mirna和蛋白质将有助于识别特定的疾病生物标志物，这些生物标志物可能被用作治疗或药物本身的靶点。
microRNAs (miRNAs) are small RNAs shown to contribute to a number of cellular processes including cell growth, differentiation, and apoptosis. MiRNAs regulate gene expression of their targets post-transcriptionally by binding to messenger RNA (mRNA), causing translational inhibition or mRNA degradation. Dysregulation of miRNA expression can promote cancer formation and progression. Research has largely focused on the function and expression of single miRNAs. However, complex physiological processes require the interaction, regulation and coordination of many molecules including miRNAs and proteins. Highly connected molecules often serve important roles in the cell. A protein–protein interaction network of established miRNA targets confirmed these proteins to be highly connected and essential to the cell, affecting tumorigenesis, cell growth/proliferation, cellular death, cell assembly, and maintenance pathways. This analysis showed that miRNAs contribute to the overall health of the prostate, and their aberrant expression destabilized homeostatic balance. This integrative network approach can reveal important miRNAs and proteins in prostate cancer that will be useful to identify specific disease biomarkers, which may be used as targets for therapeutics or drugs in themselves.
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