Dissociable neural representations of future reward magnitude and delay during temporal discounting.

Dissociable neural representations of future reward magnitude and delay during temporal discounting.
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DOI:
10.1016/j.neuroimage.2008.11.004
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发表时间:
2009-03-01
期刊:
影响因子:
5.7
通讯作者:
Knutson B
Knutson B
中科院分区:
医学1区
文献类型:
--
作者:
Ballard K;Knutson B

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在时间折扣中,个人通常更喜欢较小的立即奖励,而不是较大的延迟奖励,这意味着未来奖励的大小和延迟之间的权衡。虽然最近的功能磁共振成像(fMRI)的时间折扣的调查产生了相互矛盾的结果,没有研究集中在不同的神经基板是否响应未来奖励的大小和延迟。结合一种新的,时间分布的折扣任务与事件相关的功能磁共振成像,我们发现,而核?本(NAcc),内侧前额叶皮层(MPFC),后扣带皮层(PCC)激活与未来的奖励幅度呈正相关,背外侧前额叶皮层(DLPFC)和后顶叶皮层(PPC)激活与未来的奖励延迟呈负相关。此外,更冲动的人表现出减少NAcc激活的未来奖励的大小和更大的失活的未来奖励的延迟在MPFC,DLPFC和PPC。这些研究结果表明,虽然中脑边缘多巴胺投射区域对未来奖励的大小表现出更大的敏感性,但外侧皮质区域对未来奖励的延迟表现出更大的(负)敏感性,可能会协调不同的神经帐户的时间折扣。
In temporal discounting, individuals often prefer smaller immediate rewards to larger delayed rewards, implying a trade off between the magnitude and delay of future rewards. While recent functional magnetic resonance imaging (fMRI) investigations of temporal discounting have generated conflicting findings, no studies have focused on whether distinct neural substrates respond to the magnitude and delay of future rewards. Combining a novel, temporally distributed discounting task with event-related fMRI, we found that while nucleus accumbens (NAcc), mesial prefrontal cortical (MPFC), and posterior cingulate cortical (PCC) activation positively correlated with future reward magnitude, dorsolateral prefrontal cortical (DLPFC) and posterior parietal cortical (PPC) activation negatively correlated with future reward delay. Further, more impulsive individuals showed diminished NAcc activation to the magnitude of future rewards and greater deactivations to delays of future rewards in the MPFC, DLPFC, and PPC. These findings suggest that while mesolimbic dopamine projection regions show greater sensitivity to the magnitude of future rewards, lateral cortical regions show greater (negative) sensitivity to the delay of future rewards, potentially reconciling different neural accounts of temporal discounting.
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