IL-17, A Possible Salivary Biomarker for Preterm Birth in Females with Periodontitis
IL-17, A Possible Salivary Biomarker for Preterm Birth in Females with Periodontitis
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IL-17，可能是女性牙周炎早产的唾液生物标志物
DOI：
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发表时间：
2021
影响因子：
0.7
通讯作者：
Kirti Pattanshetti
中科院分区：
文献类型：
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作者：
Sonal Mahilkar;Sachin Malagi;Abhishek Soni;Dennis V Abraham;L. Johnson;Kirti Pattanshetti
背景以往的研究表明，慢性牙周感染可能与早产和低出生体重有关。本研究旨在探讨孕妇唾液中白介素17(IL-17)水平作为判断慢性牙周炎与早产之间是否存在关联的可能指标。目的探讨唾液IL-17水平与早产儿低出生体重儿牙周健康状况的关系。材料与方法本病例对照研究随机抽取40例18~35岁中期妊娠妇女，分为两组，第一组为20例非牙周炎孕妇，第二组为20例有牙周炎的孕妇。在妊娠中期和产后采集唾液样本。采用双抗体夹心法测定唾液标本中IL-17水平。结果2组唾液中IL-17水平明显高于1组(p <； 0.001)。早产儿、低出生体重儿与牙周炎之间差异无统计学意义。结论根据唾液中IL-17水平，未发现牙周炎与早产和低出生体重儿之间的关系。
Background Previous studies have suggested that chronic periodontal infection may be associate with preterm births and low birth weight. The present study was conducted to evaluate the levels of interleukin-17 (IL-17) in saliva samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Aim The aim of the study is to assess the relation between the periodontal health status and preterm low birth weight of the new born on the basis of salivary IL-17 levels. Materials and Methods This case–control study included a random sample of 40 female patients, aged 18 to 35 years, who were in their second trimester, assigned to two groups, Group 1 consisted of 20 pregnant females without periodontitis, Group 2 included 20 pregnant females with periodontitis. Saliva samples were obtained in the second trimester and postpartum. Saliva samples were measured by using ELISA for IL-17 levels. Results IL-17 levels in saliva were significantly higher in Group 2 than that of Group 1( p < 0.001). There was no significant difference found between the preterm and low birth weight cases and periodontitis. Conclusion This study did not find any association between the periodontitis and preterm deliveries and low birth weight cases on the basis of IL-17 levels in saliva.
影响因子：
158.5
作者：
FRASER, AM;BROCKERT, JE;WARD, RH
通讯作者：
WARD, RH
影响因子：
5.5
作者：
Blumenshine, Philip;Egerter, Susan;Braveman, Paula A.
通讯作者：
Braveman, Paula A.