Study of the normal human kidney and kidney cancer with monoclonal antibodies.
Study of the normal human kidney and kidney cancer with monoclonal antibodies.
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用单克隆抗体研究正常人肾和肾癌。
DOI：
10.3109/08860228409115852
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
N. Bander
中科院分区：
文献类型：
--
作者：
N. Bander
建立人肾癌的永生组织培养系以及自体正常肾上皮的短期系的能力提供了一种独特的系统来探测肿瘤细胞与其正常对应物之间的差异。制备了抗正常和肿瘤人肾细胞表面分化抗原的单克隆抗体。已检测到的抗原进行了生物化学表征，这些细胞的分子表型正在解开。基因表达的差异在正常和肿瘤肾细胞之间变得明显。初步结果表明，这些差异似乎具有临床意义。
The ability to establish immortal tissue culture lines of human renal cancer as well as short-term lines of autologous normal kidney epithelium offers a unique system to probe the differences between a neoplastic cell and its normal counterpart. Monoclonal antibodies have been prepared against cell surface differentiation antigens of normal and neoplastic human kidney. The detected antigens have been biochemically characterized, and the molecular phenotypes of these cells is being unraveled. Differences in gene expression are becoming apparent between the normal and neoplastic kidney cell. Preliminary results indicate that these differences appear to have clinical significance.
由小鼠单克隆抗体定义的人肾癌细胞表面抗原：组织特异性肾糖蛋白的鉴定。
DOI：
10.1073/pnas.78.8.5122
发表时间：
1981
影响因子：
11.1
作者：
Ueda,R;Ogata,S;Morrissey,DM;Finstad,CL;Szkudlarek,J;Whitmore,WF;Oettgen,HF;Lloyd,KO;Old,LJ
通讯作者：
Old,LJ