Bladder Cancer: New Insights into Its Molecular Pathology.
Bladder Cancer: New Insights into Its Molecular Pathology.
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DOI：
10.3390/cancers10040100
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发表时间：
2018-04-01
期刊：
影响因子：
5.2
通讯作者：
Inamura K
中科院分区：
文献类型：
--
作者：
Inamura K
膀胱癌是全世界最常见的癌症之一。不幸的是，由于对其分子和临床特征之间的相关性了解甚少，其临床管理方面几乎没有取得进展。越来越多的证据表明，膀胱癌由一组分子异质性疾病组成，这些疾病经历各种临床过程并具有不同的治疗反应。由于其分子亚型与临床病理特征之间的密切关联，最近提出了具体的治疗策略。本综述总结了目前对膀胱癌分子病理学的理解，包括利用高通量技术新鉴定的分子生物标志物/通路和分子亚型。它还讨论了我们对特定分子亚型的个性化治疗的理解的进展。
Bladder cancer is one of the most prevalent cancers worldwide. Unfortunately, there have been few advances in its clinical management due to a poor understanding of the correlations between its molecular and clinical features. Mounting evidence suggests that bladder cancer comprises a group of molecularly heterogeneous diseases that undergo a variety of clinical courses and possess diverse therapeutic responses. Owing to the close association between its molecular subtypes and clinicopathological features, specific therapeutic strategies have recently been suggested. This review summarizes the current understanding of the molecular pathology of bladder cancer, including its molecular biomarkers/pathways and molecular subtypes that have been newly identified using high-throughput technologies. It also discusses advances in our understanding of personalized treatments for specific molecular subtypes.
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影响因子：
4
作者：
Ecke TH;Stier K;Weickmann S;Zhao Z;Buckendahl L;Stephan C;Kilic E;Jung K
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影响因子：
158.5
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Crawford, ED
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Real, Francisco X.
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30.8
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Real, Francisco X.