Discovering chronic pain treatments: better animal models might help us get there.
Discovering chronic pain treatments: better animal models might help us get there.
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DOI：
10.1172/jci167814
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发表时间：
2023-03-01
影响因子：
15.9
通讯作者：
Ferrari, Luiz
中科院分区：
文献类型：
--
作者：
Taylor, Norman E.;Ferrari, Luiz
在过去的60年里，只有三类止痛药进入临床使用，尽管付出了密集的努力，而且需要非成瘾的疼痛治疗。失败的一个原因是使用了与人类疼痛条件缺乏机械相似性的动物模型，终点测量可能无法反映人类的疼痛体验。在这一期的JCI中，Ding、Fischer和合著者开发了三叉神经痛的三叉神经根孔撕裂孔撞击(FIIT)模型，该模型在面部、结构和预测有效性方面都比目前的模型有所改善。他们使用Flit模型来研究异常的、高度同步的皮质活动在神经病理性疼痛状态中的作用。躯体感觉皮层的初级躯体感觉皮质(S1ULP-S1J)区域的不受限制的、同步的谷氨酸能活动驱动疼痛表型。该模型建立了一个强大的工具来继续研究导致慢性疼痛的外周和中枢神经系统之间的相互作用。
Only three classes of pain medications have made it into clinical use in the past 60 years despite intensive efforts and the need for nonaddictive pain treatments. One reason for the failure involves the use of animal models that lack mechanistic similarity to human pain conditions, with endpoint measurements that may not reflect the human pain experience. In this issue of the JCI, Ding, Fischer, and co-authors developed the foramen lacerum impingement of trigeminal nerve root (FLIT) model of human trigeminal neuralgia that has improved face, construct, and predictive validities over those of current models. They used the FLIT model to investigate the role that abnormal, hypersynchronous cortical activity contributed to a neuropathic pain state. Unrestrained, synchronous glutamatergic activity in the primary somatosensory cortex upper lip and jaw (S1ULp–S1J) region of the somatosensory cortex drove pain phenotypes. The model establishes a powerful tool to continue investigating the interaction between the peripheral and central nervous systems that leads to chronic pain.
影响因子：
6.1
作者：
Phero A;Ferrari LF;Taylor NE
通讯作者：
Taylor NE