An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents.
An Adipose Tissue Atlas: An Image-Guided Identification of Human-like BAT and Beige Depots in Rodents.
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脂肪组织图谱：图像引导识别啮齿类动物中的类人 BAT 和米色库
DOI：
10.1016/j.cmet.2017.12.004
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发表时间：
2018-01-09
期刊：
影响因子：
29
通讯作者：
Oz OK
中科院分区：
文献类型：
--
作者：
Zhang F;Hao G;Shao M;Nham K;An Y;Wang Q;Zhu Y;Kusminski CM;Hassan G;Gupta RK;Zhai Q;Sun X;Scherer PE;Oz OK
[18 F]-氟脱氧葡萄糖-PET/CT（18 F-FDG-PET/CT）成像对于可视化人体代谢活性脂肪组织具有非常重要的价值，具有潜在的抗糖尿病和抗肥胖作用。为了探索小鼠在解剖学上可比较的区域中是否显示出类似人类的脂肪库，我们使用葡萄糖或脂肪酸成像示踪剂（例如通过PET/CT的18F-FDG或通过SPECT/CT成像的[123/125 I]-β-甲基-对碘苯基-十五烷酸（123/125 I-BMIPP））将脂肪库映射到小鼠中的类似库。使用这种类型的图像分析与两个探针，我们定义了大量的额外的高代谢活动的区域对应于新的脂肪垫。组织学和基因表达分析证实这些区域是真正的脂肪垫。我们的研究结果表明，啮齿类动物表现出高度的拓扑相似性的脂肪库人类。涉及葡萄糖和脂质示踪剂的研究表明，这些底物在不同的储库中具有不同的偏好，并且还表明基于脂肪酸的可视化方法可以揭示人体中的其他BAT和米色储库。人体18F-FDG-PET/CT成像对于代谢活性脂肪组织的可视化非常重要。Zhang等人分别使用PET/CT和SPECT/CT对小鼠的葡萄糖和脂质代谢进行成像，定义了脂肪库图谱，拓扑学上类似于在人类中观察到的脂肪库图谱。
[18F]-Fluorodeoxyglucose-PET/CT (18F-FDG-PET/CT) imaging has been invaluable for visualizing metabolically active adipose tissues in humans with potential anti-diabetic and anti-obesity effects. To explore whether mice display human-like fat depots in anatomically comparable regions, we mapped fat depots using glucose or fatty acid imaging tracers, such as 18F-FDG through PET/CT or [123/125I]-β-Methyl-p-iodophenyl-pentadecanoic acid (123/125I-BMIPP) with SPECT/CT imaging, to analogous depots in mice. Using this type of image analysis with both probes, we define a large number of additional areas of high metabolic activity corresponding to novel fat pads. Histological and gene expression analysis validate these regions as bona fide fat pads. Our findings indicate that rodents show a high degree of topological similarity of fat depots to humans. Studies involving both glucose and lipid tracers indicate differential preferences for these substrates in different depots and also suggest that fatty acid based visualized approaches may reveal additional BAT and beige depots in humans. 18F-FDG-PET/CT imaging in humans has been invaluable for visualizing metabolically active adipose tissues. Using PET/CT and SPECT/CT for imaging glucose and lipid metabolism in mice respectively, Zhang et al. define an atlas of fat depots, topologically analogous to those observed in humans.
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影响因子：
3.3
作者：
Cohen P;Spiegelman BM
通讯作者：
Spiegelman BM
影响因子：
3.7
作者：
Giedd, Kenneth N;Bergmann, Steven R
通讯作者：
Bergmann, Steven R
影响因子：
29
作者：
Martínez de Morentin PB;González-García I;Martins L;Lage R;Fernández-Mallo D;Martínez-Sánchez N;Ruíz-Pino F;Liu J;Morgan DA;Pinilla L;Gallego R;Saha AK;Kalsbeek A;Fliers E;Bisschop PH;Diéguez C;Nogueiras R;Rahmouni K;Tena-Sempere M;López M
通讯作者：
López M
影响因子：
3.2
作者：
Mirbolooki MR;Constantinescu CC;Pan ML;Mukherjee J
通讯作者：
Mukherjee J
影响因子：
29
作者：
Cypess AM;Weiner LS;Roberts-Toler C;Franquet Elía E;Kessler SH;Kahn PA;English J;Chatman K;Trauger SA;Doria A;Kolodny GM
通讯作者：
Kolodny GM