Transverse relaxation of saline and plasma using Mn(II), HSA–EDTA–Mn, and HSA–EDTA–Gd: Application to erythrocyte water exchange

Transverse relaxation of saline and plasma using Mn(II), HSA–EDTA–Mn, and HSA–EDTA–Gd: Application to erythrocyte water exchange
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使用 Mn(II)、HSA-EDTA-Mn 和 HSA-EDTA-Gd 进行盐水和血浆的横向弛豫:在红细胞水交换中的应用

DOI:
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发表时间:
1987
影响因子:
3.3
通讯作者:
J. Goldstein
J. Goldstein
中科院分区:
医学3区
文献类型:
--
作者:
G. Caines;C. Morgan;R. C. Long;J. Goldstein

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比较了Mn(II)‐和Gd(III)‐乙二胺四乙酸(EDTA)‐人血清白蛋白(HSA)复合物与MnCl2在人血浆和等渗盐水中的增强作用。生理浓度的HSA下,生理盐水中的HSA - edta - mn和HSA - edta - gd产生的T2与4% HSA生理盐水中的2mm MnCl2相当。上述试剂是测量红细胞悬浮液中水交换率的新型和潜在有用的松弛剂。使用这些新试剂在20至37℃的温度范围内测定了红细胞膜上的水交换速率©1987学术出版社,Inc.。
Enhancements of 1H nuclear magnetic transverse relaxation rates by Mn(II)‐ and Gd(III)‐ethylenediaminetetraacetic acid (EDTA)‐human serum albumin (HSA) complexes are compared with MnCl2 in human plasma and isotonic saline. HSA–EDTA–Mn and HSA–EDTA–Gd in saline, at physiological concentrations of HSA, afforded T2's comparable to 2 mM MnCl2 in 4% HSA saline. The above reagents are new and potentially useful relaxation agents for the measurement of H2O exchange rates in erythrocyte suspensions. The exchange rate of water across the red cell membrane was determined using these new reagents over the temperature range from 20 to 37°C. © 1987 Academic Press, Inc.
DOI: 10.1016/0730-725x(85)90004-9
发表时间: 1985-01-01
影响因子: 2.5
作者:
LAUFFER R B;BRADY T J
通讯作者: BRADY T J