Factor V leiden and ischemic stroke risk: the Genetics of Early Onset Stroke (GEOS) study.
Factor V leiden and ischemic stroke risk: the Genetics of Early Onset Stroke (GEOS) study.
复制标题
DOI：
10.1016/j.jstrokecerebrovasdis.2011.10.007
复制
发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Kittner SJ
中科院分区：
文献类型：
--
作者：
Hamedani AG;Cole JW;Cheng Y;Sparks MJ;O'Connell JR;Stine OC;Wozniak MA;Stern BJ;Mitchell BD;Kittner SJ
莱顿因子V（FVL）与儿童缺血性卒中有关，但与成人无关。尽管FVL突变与静脉血栓形成风险增加相关，但其与年轻人缺血性卒中的关系仍不确定。因此，我们在早发性卒中遗传学（GEOS）研究的参与者中研究了FVL和缺血性卒中之间的关系。一项基于人群的病例对照研究确定了354名女性和476名男性，年龄在15-49岁之间，首次发生缺血性卒中，907名对照。患者特异性数据包括血管危险因素、FVL基因型，以及根据改良吐司标准确定的缺血性卒中亚型。Logistic回归用于计算整个人群和按危险因素和缺血性卒中亚型分层的亚组的比值比。缺血性卒中患者（3.6%，95%CI：2.5%-5.1%）和非卒中对照组（3.8%，95%CI：2.7%-5.2%）之间FVL突变的频率相似。当病例仅限于病因不明的卒中患者时，该频率无显著变化（4.1%，95% CI：2.6%-6.4%）。在年轻人中，我们没有发现莱顿因子V与所有缺血性卒中或病因不明的卒中亚组之间相关的证据。
Factor V Leiden (FVL) has been associated with ischemic stroke in children, but not in adults. Although the FVL mutation is associated with increased risk for venous thrombosis, its association with ischemic stroke in young adults remains uncertain. Therefore, we examined the association between FVL and ischemic stroke in participants of the Genetics of Early Onset Stroke (GEOS) Study. A population-based case-control study identified 354 women and 476 men aged 15–49 years with first-ever ischemic stroke, and 907 controls. Participant-specific data included vascular risk factors, FVL genotype and, for cases, the ischemic stroke subtype by modified TOAST criteria. Logistic regression was used to calculate odds ratios for the entire population and for subgroups stratified by risk factors and ischemic stroke subtype. The frequency of the FVL mutation was similar between ischemic stroke patients (3.6%, 95% CI: 2.5%–5.1%) and non-stroke controls (3.8%, 95% CI: 2.7%–5.2%). This frequency did not change significantly when cases were restricted to patients with stroke of undetermined etiology (4.1%, 95% CI: 2.6%–6.4%). Among young adults, we found no evidence for an association between Factor V Leiden and either all ischemic stroke or the subgroup with stroke of undetermined etiology.
登录
查看更多内容
影响因子：
6.7
作者：
Aznar, J;Mira, Y;Estellés, A
通讯作者：
Estellés, A
影响因子：
8.3
作者：
Madonna, P;de Stefano, V;Di Minno, G
通讯作者：
Di Minno, G
影响因子：
8.3
作者：
JOHNSON, CJ;KITTNER, SJ;PRICE, TR
通讯作者：
PRICE, TR
影响因子：
158.5
作者：
Kittner, SJ;Stern, BJ;Wozniak, MA
通讯作者：
Wozniak, MA
影响因子：
1.1
作者：
de Paula Sabino, Adriano;Ribeiro, Daniel Dias;Fernandes, Ana Paula
通讯作者：
Fernandes, Ana Paula