Breast cancer survivors' health-related quality of life : racial differences and comparisons with noncancer controls.
Breast cancer survivors' health-related quality of life : racial differences and comparisons with noncancer controls.
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作者：
Paskett ED;Alfano CM;Davidson MA;Andersen BL;Naughton MJ;Sherman A;McDonald PG;Hays J
少数族裔妇女很少的小样本和/或没有与没有癌症病史的同龄人进行比较的情况限制了先前关于乳腺癌幸存者健康相关生活质量(HRQOL)存在种族差异的研究。这项研究不仅比较了非裔美国人和白人乳腺癌幸存者的HRQL，而且还比较了这些女性和没有癌症病史的同一种族女性的HRQL。数据来自女性健康倡议-观察性研究，包括5021名癌症幸存者和88532名没有癌症病史的女性。多变量回归分析估计了乳腺癌幸存者基线HRQOL(RAND36)、抑郁症状(CES-D简写)和睡眠质量(WHIIRS)的差异。非洲裔美国人乳腺癌幸存者报告说，与白人幸存者相比，他们的身体功能和总体健康状况更差。在非裔美国人中，幸存者报告说，与没有癌症病史的女性相比，由于身体健康、疼痛、一般健康和活力而造成的角色限制更严重。这一点在那些最近确诊的患者中最为明显。两组间最显著的差异在幅度上很小(Cohen‘s d=0.21-0.36)。这些结果增加了人们对癌症差异的了解，因为这些结果表明，与白人幸存者和未患癌症的非裔美国女性相比，非裔美国女性的身体HRQOL下降幅度很小，但具有临床意义。由于非裔美国女性也面临更高级别的肿瘤和更高的乳腺癌死亡率的诊断，需要更多的研究来检查非裔美国乳腺癌幸存者的身体和心理社会经历，以阐明导致较差预后的机制。
Small samples with few minority women and/or the absence of comparisons to peers without cancer histories have limited previous research suggesting racial differences in breast cancer survivors’ health-related quality of life (HRQoL). The present study not only compares HRQoL of African American and white breast cancer survivors, but also compares the HRQoL of these women to that of same race women with no cancer history. Data from the Women’s Health Initiative-Observational Study were used including 5,021 cancer survivors and 88,532 women without a history of cancer. Multivariable regression analyses estimated differences in breast cancer survivors’ baseline HRQoL (RAND36), depressive symptoms (CES-D short-form), and sleep quality (WHIIRS). African American breast cancer survivors reported worse physical functioning and general health compared to white survivors. Among African Americans, survivors reported worse role limitations due to physical health, pain, general health, and vitality than women without a history of cancer. This was most evident in those with more recent diagnoses. Most significant differences between groups were small in magnitude (Cohen’s d=.21-.36). These results add to the increasing knowledge of cancer disparities by showing that African American women have small but clinically meaningful decrements in physical HRQoL compared to white survivors and to African American women without cancer. Since African American women also face diagnosis with higher grade tumors and higher breast cancer mortality, more research is needed to examine the physical and psychosocial experiences of African American breast cancer survivors to elucidate the mechanisms leading to poorer outcomes.
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影响因子：
3.6
作者：
Levine, DW;Kaplan, RM;Shumaker, SA
通讯作者：
Shumaker, SA
影响因子：
3.6
作者：
Gotay, CC;Holup, JL;Pagano, I
通讯作者：
Pagano, I
影响因子：
3.6
作者：
Deimling, GT;Kahana, B;Schaefer, ML
通讯作者：
Schaefer, ML
影响因子：
6.2
作者：
ANDERSEN, BL
通讯作者：
ANDERSEN, BL
DOI：
10.1016/s0197-2456(05)80014-5
发表时间：
1991-08-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
GUYATT, G;FEENY, D;PATRICK, D
通讯作者：
PATRICK, D