High-density surface electromyography to assess motor unit firing rate in Charcot-Marie-Tooth disease type 1A patients
High-density surface electromyography to assess motor unit firing rate in Charcot-Marie-Tooth disease type 1A patients
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高密度表面肌电图评估 1A 型腓骨肌萎缩症患者运动单位放电率
DOI：
10.1016/j.clinph.2020.11.040
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发表时间：
2021
影响因子：
4.7
通讯作者：
Nakagawa Masanori
中科院分区：
文献类型：
--
作者：
Noto Yu-ichi;Watanabe Kohei;Holobar Ale?;Kitaoji Takamasa;Tsuji Yukiko;Kojima Yuta;Kitani-Morii Fukiko;Mizuno Toshiki;Nakagawa Masanori
目的应用高密度表面肌电信号(Surface-EMG)和运动单位分解(MU)分析方法，探讨1A型夏科-玛丽-牙病(CMT1A)患者运动单位(MU)放电频率的特点及其纵向变化。方法对19例CMT1A型患者和21例力量匹配的健康对照组进行股外侧肌等长伸膝时的表面肌电描记。经过分解分析，计算出个体识别的MU的瞬时放电率(IFRS)。对于CMT1A患者，在基线后一年进行随访测量。比较CMT1a患者和对照组在基线时以及CMT1a患者基线和一年后的IFRS和临床变量。结果CMT1a患者MUS的IFRS平均低于对照组。在加速收缩的不同力量水平下，这是正确的(p<；)0.01。例如，10.3(CMT1a患者)和12.2(对照组)在22.5-27.5%的最大自愿收缩(MVC)和持续收缩期间的任何时间点招募的MU的每秒脉搏(Pps)(P<0.001)。例如，在10-20秒分别为8.0vs.9.3PPS)。在CMT1A型患者中，持续收缩0-10秒的平均IFRS较一年前显著降低(从8.06PPS降至7.52PPS；p=0.027)，而疾病严重程度评分和膝关节伸展的MVC值并没有随时间的变化而改变。
ObjectiveThe aim of this study was to elucidate the characteristics of the motor unit (MU) firing rate in Charcot-Marie-Tooth disease type 1A (CMT1A) patients and its longitudinal change using high-density surface-electromyography (surface-EMG) and MU decomposition analysis.MethodsNineteen patients with CMT1A and 21 force-matched healthy controls prospectively underwent surface-EMG recording of the vastus lateralis muscle during ramp-up and sustained contractions on performing isometric knee extension. After decomposition analysis, instantaneous firing rates (IFRs) of individually identified MUs were calculated. In CMT1A patients, follow-up measurements were performed one year after the baseline. Comparison of IFRs and clinical variables between CMT1A patients and controls at the baseline and between the baseline and after one year in CMT1A patients was performed.ResultsMean IFRs of MUs were lower in CMT1A patients than in controls. This was true at various force levels in ramp-up contractions (p < 0.01. e.g., 10.3 (CMT1A patients) vs. 12.2 (controls) pulses-per-second (pps) at 22.5–27.5% of maximal voluntary contraction (MVC) in MUs recruited at <7.5% of MVC) and at any time-point during sustained contractions (p < 0.001. e.g., 8.0 vs. 9.3 pps, respectively, at 10–20 seconds). In CMT1A patients, mean IFRs at 0–10 seconds of sustained contraction were significantly decreased over one year (from 8.06 to 7.52 pps; p = 0.027), whereas the disease severity score and MVC of knee extension did not change over time.ConclusionCMT1A patients had a lower individual MU firing rate.SignificanceThe MU firing rate is a potential short-term biomarker of axonal damage in CMT1A patients.
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影响因子：
9.3
作者：
Verhamme C;de Haan RJ;Vermeulen M;Baas F;de Visser M;van Schaik IN
通讯作者：
van Schaik IN
影响因子：
3.2
作者：
Roger M. Nelson;Gary L Soderberg;Nancy L. Urbscheit
通讯作者：
Nancy L. Urbscheit
影响因子：
--
作者：
Watanabe, Kohei;Holobar, Ales;Moritani, Toshio
通讯作者：
Moritani, Toshio
影响因子：
5.1
作者：
Padua, L.;Pazzaglia, C.;Contini, M.
通讯作者：
Contini, M.
年龄对运动单位动作电位特性的影响：ADEMG 分析
影响因子：
11.2
作者：
Januarye E. Howard;K. McGill;L. Dorfman
通讯作者：
L. Dorfman