Infantile hydrocephalus: a review of epidemiology, classification and causes.

Infantile hydrocephalus: a review of epidemiology, classification and causes.
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DOI:
10.1016/j.ejmg.2014.06.002
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发表时间:
2014-08
影响因子:
1.9
通讯作者:
Dobyns WB
Dobyns WB
中科院分区:
医学4区
文献类型:
--
作者:
Tully HM;Dobyns WB

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脑积水是一种常见但复杂的疾病,由导致进行性脑室扩张的CSF流动的物理或功能性阻塞引起。虽然最近估计脑积水影响1.1/1000婴儿,但很少有系统评估这个年龄组脑积水的原因,这使得它成为一个具有挑战性的条件,作为科学家或临床医生。在这里,我们回顾了婴儿脑积水的流行病学,分类和发病机制的当代文献。我们描述了脑积水的主要环境和遗传原因,目的是提供一个框架来评估脑积水婴儿并指导未来的研究。
Hydrocephalus is a common but complex condition caused by physical or functional obstruction of CSF flow that leads to progressive ventricular dilatation. Though hydrocephalus was recently estimated to affect 1.1 in 1,000 infants, there have been few systematic assessments of the causes of hydrocephalus in this age group, which makes it a challenging condition to approach as a scientist or as a clinician. Here, we review contemporary literature on the epidemiology, classification and pathogenesis of infantile hydrocephalus. We describe the major environmental and genetic causes of hydrocephalus, with the goal of providing a framework to assess infants with hydrocephalus and guide future research.
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