Hemodynamic Effects of Anti-Vascular Endothelial Growth Factor Injections on Optical Coherence Tomography Angiography in Diabetic Macular Edema Eyes.
Hemodynamic Effects of Anti-Vascular Endothelial Growth Factor Injections on Optical Coherence Tomography Angiography in Diabetic Macular Edema Eyes.
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DOI：
10.1167/tvst.11.10.5
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发表时间：
2022-10-03
影响因子：
3
通讯作者：
Fawzi, Amani A.
中科院分区：
文献类型：
--
作者：
Song, Jessica;Huang, Bonnie B.;Ong, Janice X.;Konopek, Nicholas;Fawzi, Amani A.
应用光学相干断层扫描血管造影术(OCTA)评价糖尿病黄斑水肿患者注射抗血管内皮生长因子(VEGF)后视网膜血流动力学变化。我们对两种不同的阈值方法进行了比较，以确定最准确的方法来研究糖尿病黄斑水肿眼的血管密度(VD)。前瞻性研究对象为22例26眼(年龄60.2±13.7岁)，在注射抗血管内皮生长因子前后进行OCTA扫描(平均间隔31.1±17.3天)。我们分析了调整后的血流指数、Vd和黄斑旁区域(内环为3 mm，内圈为1 mm)的骨架血管长度密度，以及全厚中心凹无血管带面积和中心凹厚度(CFT)。以平均扫描Vd为基础，在不同的神经丛上比较了两种不同的Vd算法。纵向变化通过修正中心凹厚度和Q分数的广义线性模型进行评估。随诊时DCP层调整血流指数显著降低(P=0.010)。此外，中心凹无血管区(P<；0.001)和中心凹厚度(P=0.003)在随访时较基线显著降低。两种阈值算法的比较表明，基于血管长度密度的阈值方法对DCPVD的定量更为准确。经OCTA扫描调整后的DCP层血流指数明显降低，提示注射抗血管内皮生长因子抗体后，视网膜深部血流中断，视网膜深部血流灌注减少。我们的结果还强调了这样一个事实，即阈值方法的选择对于糖尿病黄斑水肿患者的DCP定量尤为关键。结果证实注射抗血管内皮生长因子后视网膜深部毛细血管血流受损。
To evaluate retinal hemodynamic responses to anti-vascular endothelial growth factor (VEGF) injection in eyes with diabetic macular edema using optical coherence tomography angiography (OCTA). We performed a comparison of two different thresholding methods to identify the most accurate for studying the vessel density (VD) in diabetic macular edema eyes. The study prospectively included 26 eyes of 22 subjects (aged 60.2 ± 13.7 years) who underwent OCTA scan before and after anti-VEGF injection (mean interval between OCTA = 31.1 ± 17.3 days). We analyzed adjusted flow index, VD, and Skeletonized vessel length density in the parafoveal area (3-mm annulus with a 1-mm inner circle), along with full-thickness fovea avascular zone area and central foveal thickness (CFT). Using averaged scans VD as the ground truth, we compared two different algorithms for VD at the different plexuses. Longitudinal changes were assessed using a generalized linear model correcting for central foveal thickness and Q-score. We found significantly decreased adjusted flow index in the DCP layer (P = 0.010) at the follow-up. Furthermore, foveal avascular zone (P < 0.001) and central foveal thickness (P = 0.003) showed significant decrease on follow-up compared with baseline. Comparing the thresholding algorithms showed that vessel length density–based thresholding was more accurate for quantifying the DCP VD. The adjusted flow index decreased significantly in the DCP layer on follow-up OCTA scan, suggesting vascular flow disruption and decreased deep retinal perfusion after anti-VEGF injection. Our results also highlight the fact that the choice of thresholding method is particularly critical for DCP quantification in eyes with diabetic macular edema. Findings confirmed impaired deep retinal capillary flow after anti-VEGF injection.
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影响因子：
3.7
作者：
Ong JX;Kwan CC;Cicinelli MV;Fawzi AA
通讯作者：
Fawzi AA
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
4.2
作者：
Mehta, Nihaal;Liu, Keke;Waheed, Nadia K.
通讯作者：
Waheed, Nadia K.
DOI：
10.1097/iae.0000000000000859
发表时间：
2015-11-01
影响因子：
3.3
作者：
Couturier, Aude;Mane, Valerie;Tadayoni, Ramin
通讯作者：
Tadayoni, Ramin
影响因子：
8.1
作者：
Hwang TS;Zhang M;Bhavsar K;Zhang X;Campbell JP;Lin P;Bailey ST;Flaxel CJ;Lauer AK;Wilson DJ;Huang D;Jia Y
通讯作者：
Jia Y