A functional magnetic resonance imaging study of human brain in pain-related areas induced by electrical stimulation with different intensities.
A functional magnetic resonance imaging study of human brain in pain-related areas induced by electrical stimulation with different intensities.
复制标题
不同强度电刺激诱发的人脑疼痛相关区域的功能磁共振成像研究。
DOI：
10.4103/0028-3886.73748
复制
发表时间：
2010-11
期刊：
影响因子：
2.7
通讯作者：
中科院分区：
文献类型：
--
作者：
背景
疼痛相关的研究主要通过传统的方法进行，缺乏对解剖位置的严格分析。功能性磁共振成像（fMRI）是一种无创性的神经活动检测方法，具有精确定位相关激活的能力。此外，很少有研究使用改变强度的疼痛刺激来研究人脑中相关的功能核团。
目的
本研究主要利用功能磁共振成像技术研究不同强度电刺激引起的痛相关激活。进一步分析不同痛敏感神经元的电生理特性，构建与不同强度痛刺激相对应的痛调节网络。
材料和方法
12名志愿者接受不同的电刺激进行功能扫描。收集并分析数据，以生成与疼痛相关的相应功能激活图和反应时间曲线。
结果
常见的激活主要位于几个特定的区域，包括次级躯体感觉皮层（SII），前扣带皮层（ACC），丘脑和其他大脑区域。此外，无害电刺激主要激活SII和丘脑的外侧部分，以及后丘脑，前ACC，而有害电刺激主要激活SII和丘脑的内侧部分，以及前丘脑，后ACC，具有更大的延伸和更大的强度。
结论
利用fMRI技术研究了不同脑区对电刺激的反应模式，提示相应的痛敏感神经元可能对疼痛的特定方面进行加工。阐明疼痛相关脑区的功能将有助于理解人脑对疼痛的精细调制。
BACKGROUND
Pain-related studies have mainly been performed through traditional methods, which lack the rigorous analysis of anatomical locations. Functional magnetic resonance imaging (fMRI) is a noninvasive method detecting neural activity, and has the ability to precisely locate related activations in vivo. Moreover, few studies have used painful stimulation of changed intensity to investigate relevant functioning nuclei in the human brain.
AIM
This study mainly focused on the pain-related activations induced by electrical stimulation with different intensities using fMRI. Furthermore, the electrophysiological characteristics of different pain-susceptible-neurons were analyzed to construct the pain modulatory network, which was corresponding to painful stimulus of changed intensity.
MATERIALS AND METHODS
Twelve volunteers underwent functional scanning receiving different electrical stimulation. The data were collected and analyzed to generate the corresponding functional activation maps and response time curves related to pain.
RESULTS
The common activations were mainly located in several specific regions, including the secondary somatosensory cortex (SII), insula, anterior cingulate cortex (ACC), thalamus, and other cerebral regions. Moreover, innocuous electrical stimulation primarily activated the lateral portions of SII and thalamus, as well as the posterior insula, anterior ACC, whereas noxious electrical stimulation primarily activated the medial portions of SII and thalamus, as well as the anterior insula, the posterior ACC, with larger extensions and greater intensities.
CONCLUSION
Several specified cerebral regions displayed different response patterns during electrical stimulation by means of fMRI, which implied that the corresponding pain-susceptible-neurons might process specific aspects of pain. Elucidation of functions on pain-related regions will help to understand the delicate pain modulation of human brain.
影响因子：
7.4
作者：
Kong J;Loggia ML;Zyloney C;Tu P;LaViolette P;Gollub RL
通讯作者：
Gollub RL
影响因子：
1.7
作者：
Davis, KD;Kwan, CL;Mikulis, DJ
通讯作者：
Mikulis, DJ