Effects of modulating erythrocyte membrane cholesterol on Rho(D) antigen expression.
Effects of modulating erythrocyte membrane cholesterol on Rho(D) antigen expression.
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调节红细胞膜胆固醇对 Rho(D) 抗原表达的影响。
DOI：
10.1016/0006-291x(80)90870-0
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发表时间：
1980
影响因子：
3.1
通讯作者：
Maniatis,A
中科院分区：
文献类型：
--
作者：
Basu,MK;Flamm,M;Schachter,D;Bertles,JF;Maniatis,A
Alteration of Rho(D)-antigen expression in Rh-positive erythrocytes after modification of membrane fluidity has recently been demonstrated by indirect fluorescence staining. The isolation of D-antigen from Rh-negative erythrocyte membranes has also recently been claimed. We therefore attempted quantification of D-antigen sites in modified Rh-positive and Rh-negative cells by the direct radiolabelled (125I) antibody uptake technique. The cholesterol/phospholipid molar ratio of erythrocytes was modified with resulting membrane-cholesterol enrichment or depletion.125I-anti-D uptake doubled in enriched Rh-positive erythrocytes, and was decreased in depleted Rh-positive erythrocytes. No change in anti-D uptake could be shown for Rh-negative erythrocytes similarly modified. If the mechanism for enhanced D-antigen expression in cholesterol enriched erythrocytes is vertical displacement of antigen, our inability to unmask the D-antigen in Rh-negative erythrocytes suggests that it is deeply buried in the lipid matrix.
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Rh 抗原活性需要磷脂。
影响因子：
4.8
作者：
F. Green
通讯作者：
F. Green
DOI：
10.1042/bj0880435
发表时间：
1963
期刊：
The Biochemical journal
影响因子：
--
作者：
N. Hughes;B. Gardner;R. Telford
通讯作者：
R. Telford
从人红细胞膜中分离纯化Rh(D)血型受体成分。
DOI：
--
发表时间：
1975
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
C. V. Abraham;S. Bakerman
通讯作者：
S. Bakerman
影响因子：
3.5
作者：
SHINITZKY, M
通讯作者：
SHINITZKY, M
I-131 痕量标记的人抗 Rho(D) 与红细胞的反应。
DOI：
10.1172/jci103800
发表时间：
1959
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
S. P. Masouredis
通讯作者：
S. P. Masouredis