Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study.
Dietary Polyamines Intake and Risk of Colorectal Cancer: A Case-Control Study.
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膳食多胺摄入量与结直肠癌风险：一项病例对照研究
DOI：
10.3390/nu12113575
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发表时间：
2020-11-22
期刊：
影响因子：
5.9
通讯作者：
Zhang CX
中科院分区：
文献类型：
--
作者：
Huang CY;Fang YJ;Abulimiti A;Yang X;Li L;Liu KY;Zhang X;Feng XL;Chen YM;Zhang CX
多胺（包括腐胺、亚精胺和精胺）是细胞增殖和分化所必需的小阳离子分子。很少有研究探讨饮食中多胺摄入与结直肠癌风险的关系。本研究的目的是评估总多胺，腐胺，亚精胺和精胺的摄入量与结直肠癌的风险在中国。2010年7月至2019年4月期间，共招募了2502例结直肠癌病例和2538名年龄（间隔5年）和性别匹配的对照组。调整各种潜在混杂因素后，通过多变量非条件Logistic回归计算比值比（OR）和95%置信区间（CI）。总多胺、腐胺和亚精胺的摄入量较高与结直肠癌风险降低显著相关。最高摄入量与最低摄入量四分位数相比的调整OR为0.60（95% CI 0.50，0.72; Ptrend < 0.001）总多胺，0.35腐胺和亚精胺分别为0.79（95% CI 0.66，0.95; Ptrend = 0.001）。然而，较高的精胺摄入量与结直肠癌风险增加相关，调整后的OR为1.58（95%CI 1.29，1.93; P趋势< 0.001）。这些数据表明，总多胺，腐胺和亚精胺的摄入量较高，以及精胺的摄入量较低，与结直肠癌的风险降低有关。
Polyamines (including putrescine, spermidine, and spermine) are small, cationic molecules that are necessary for cell proliferation and differentiation. Few studies have examined the association of dietary polyamines intake with colorectal cancer risk. The aim of this study was to evaluate total polyamines, putrescine, spermidine, and spermine intake in relation to colorectal cancer risk in China. In total, 2502 colorectal cancer cases and 2538 age-(5-year interval) and sex-matched controls were recruited from July 2010 to April 2019. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by multivariable unconditional logistic regression after adjustment for various potential confounding factors. Higher intake of total polyamine, putrescine and spermidine was significantly associated with reduced risk of colorectal cancer. The adjusted ORs for the highest compared with the lowest quartile of intake were 0.60 (95% CI 0.50, 0.72; Ptrend < 0.001) for total polyamines, 0.35 (95% CI 0.29, 0.43; Ptrend < 0.001) for putrescine and 0.79 (95% CI 0.66, 0.95; Ptrend = 0.001) for spermidine, respectively. However, higher intake of spermine was associated with increased risk of colorectal cancer, with an adjusted OR of 1.58 (95% CI 1.29, 1.93; Ptrend < 0.001). This data indicate that higher intake of total polyamines, putrescine and spermidine, as well as lower intake of spermine, is associated with a decreased risk of colorectal cancer.
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影响因子：
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作者：
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