Loss of E‐cadherin and p27 expression is associated with head and neck squamous tumorigenesis

Loss of E‐cadherin and p27 expression is associated with head and neck squamous tumorigenesis
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E-钙粘蛋白和 p27 表达的丧失与头颈部鳞状细胞肿瘤的发生有关

DOI:
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发表时间:
2005
期刊:
影响因子:
6.2
通讯作者:
V. Papadimitrakopoulou
V. Papadimitrakopoulou
中科院分区:
医学1区
文献类型:
--
作者:
E. Massarelli;E. Brown;Ngoc K. Tran;Diane D. Liu;J. Izzo;J. Lee;A. El;W. Hong;V. Papadimitrakopoulou

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在肿瘤性头颈部病变中,已经发现E-钙粘蛋白表达的丢失或减少是晚期事件,并且与侵袭相关。低p27水平与许多不同肿瘤(包括喉癌)的预后不良相关。作者研究了头颈部肿瘤发生早期阶段的p27和E‐cadherin蛋白表达,并单独评估了其预测作用以及与癌变的相关性。
In neoplastic head and neck lesions, it has been found that the loss or reduction in E‐cadherin expression is a late event and is associated with invasion. Low p27 levels have been associated with a poor prognosis in many different tumors, including laryngeal carcinoma. The authors investigated p27 and E‐cadherin protein expression in the early stages of head and neck tumorigenesis and evaluated their predictive roles individually and in association with carcinogenesis.
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