Roles of Long Noncoding RNAs in Conferring Glioma Progression and Treatment.
Roles of Long Noncoding RNAs in Conferring Glioma Progression and Treatment.
复制标题
长非编码 RNA 在神经胶质瘤进展和治疗中的作用
DOI：
10.3389/fonc.2021.688027
复制
发表时间：
2021
影响因子：
4.7
通讯作者：
Meng X
中科院分区：
文献类型：
--
作者：
Qin J;Jiang C;Cai J;Meng X
随着生物医学的发展，我们对脑胶质瘤这一最常见的颅内原发肿瘤的认识也越来越全面。不幸的是，即使采用标准的综合治疗，即手术切除、术后放疗和化疗，胶质母细胞瘤(GBM)患者的预后仍然很差，复发率也很高。缺乏有效的生物标记物是造成这些不良结果的主要原因，而可靠的治疗靶点对于改善胶质瘤患者的预后是不可或缺的。因此，准确的诊断和准确的预后标记物以及有希望的治疗靶点的识别引起了研究人员的极大关注。令人鼓舞的是，越来越多的证据表明，长非编码RNA(LncRNAs)在包括胶质瘤在内的各种人类肿瘤的发病机制和肿瘤发生中发挥着重要作用。然而，lncRNAs调控胶质瘤细胞增殖、侵袭和迁移等多种生物学行为的潜在机制仍然知之甚少。因此，本文在前人研究的基础上，进一步总结了近年来在胶质瘤中lncRNA调控方面的研究进展，并阐述了lncRNA作为诊断和预后标记物和治疗靶点的潜力。
Accompanying the development of biomedicine, our knowledge of glioma, one of the most common primary intracranial carcinomas, is becoming more comprehensive. Unfortunately, patients with glioblastoma (GBM) still have a dismal prognosis and a high relapse rate, even with standard combination therapy, namely, surgical resection, postoperative radiotherapy and chemotherapy. The absence of validated biomarkers is responsible for the majority of these poor outcomes, and reliable therapeutic targets are indispensable for improving the prognosis of patients suffering from gliomas. Identification of both precise diagnostic and accurate prognostic markers and promising therapeutic targets has therefore attracted considerable attention from researchers. Encouragingly, accumulating evidence has demonstrated that long noncoding RNAs (lncRNAs) play important roles in the pathogenesis and oncogenesis of various categories of human tumors, including gliomas. Nevertheless, the underlying mechanisms by which lncRNAs regulate diverse biological behaviors of glioma cells, such as proliferation, invasion and migration, remain poorly understood. Consequently, this review builds on previous studies to further summarize the progress in the field of lncRNA regulation of gliomas over recent years and addresses the potential of lncRNAs as diagnostic and prognostic markers and therapeutic targets.
登录
查看更多内容
影响因子：
8.8
作者：
Guo, Jizhe;Shen, Shuyuan;Xue, Yixue
通讯作者：
Xue, Yixue
影响因子：
11.1
作者：
Bonasio R;Shiekhattar R
通讯作者：
Shiekhattar R
影响因子：
3.1
作者：
Gao Y;Xu Y;Wang J;Yang X;Wen L;Feng J
通讯作者：
Feng J
影响因子：
9
作者：
Cheng, Zhihua;Wang, Guangyu;Guo, Zhilin
通讯作者：
Guo, Zhilin
长非编码RNA MIAT通过作为竞争性内源RNA调节血液肿瘤屏障通透性
影响因子：
9
作者：
He J;Xue Y;Wang Q;Zhou X;Liu L;Zhang T;Shang C;Ma J;Ma T
通讯作者：
Ma T