Advances and Future Perspectives in 4D Bioprinting.
Advances and Future Perspectives in 4D Bioprinting.
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DOI：
10.1002/biot.201800148
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发表时间：
2018-12
影响因子：
4.7
通讯作者：
Khademhosseini A
中科院分区：
文献类型：
--
作者：
Ashammakhi N;Ahadian S;Zengjie F;Suthiwanich K;Lorestani F;Orive G;Ostrovidov S;Khademhosseini A
三维打印的结构是静态的，不能概括组织的动态性质。四维(4D)生物打印已经出现，包括使用刺激响应生物材料和/或细胞以预定方式在打印结构中的构象变化。制造这种动态结构的能力将使我们能够制造出可以经历形态变化的组织结构。此外，其他领域(生物驱动、生物机器人和生物传感)将受益于4D生物打印的发展。在这里，我们讨论了刺激响应型生物材料作为4D生物打印的潜在生物墨水。自然细胞力量也可以被整合到4D生物打印结构中。我们引入数学模型来预测4D打印结构的转变和最终状态。还介绍了4D生物打印的不同潜在应用。最后，我们强调了这一新兴技术在生物医学中的未来前景。四维(4D)生物打印已经出现，包括使用刺激响应生物材料和/或细胞以预定方式在打印结构中的构象变化。在这里，描述了4D生物打印的不同潜在应用。我们还引入了数学模型来预测4D打印结构的转变和最终状态。
Three-dimensionally printed constructs are static and do not recapitulate the dynamic nature of tissues. Four-dimensional (4D) bioprinting has emerged to include conformational changes in printed structures in a predetermined fashion using stimuli-responsive biomaterials and/or cells. The ability to make such dynamic constructs would enable us to fabricate tissue structures that can undergo morphological changes. Furthermore, other fields (bioactuation, biorobotics, and biosensing) will benefit from developments in 4D bioprinting. Here, we discuss stimuli-responsive biomaterials as potential bioinks for 4D bioprinting. Natural cell forces can also be incorporated into 4D bioprinted structures. We introduce mathematical modelling to predict the transition and final state of 4D printed constructs. Different potential applications of 4D bioprinting are also described. Finally, we highlight future perspectives for this emerging technology in biomedicine. Four-dimensional (4D) bioprinting has emerged to include conformational changes in printed structures in a predetermined fashion using stimuli-responsive biomaterials and/or cells. Here, different potential applications of 4D bioprinting are described. We also introduce mathematical modelling to predict the transition and final state of 4D printed constructs.
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影响因子：
6.7
作者：
Ahadian S;Khademhosseini A
通讯作者：
Khademhosseini A
影响因子：
3.9
作者：
Fantino, Erika;Roppolo, Ignazio;Yang, Jun
通讯作者：
Yang, Jun
影响因子：
9.5
作者：
Credi, Caterina;Fiorese, Alessandro;Turri, Stefano
通讯作者：
Turri, Stefano
影响因子：
46.2
作者：
Brown TE;Anseth KS
通讯作者：
Anseth KS
影响因子：
15.1
作者：
Bagheri, Ali;Arandiyan, Hamidreza;Boyer, Cyrille;Lim, May
通讯作者：
Lim, May