Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems.
Lanthanide-Doped Upconversion Nanoparticles: Emerging Intelligent Light-Activated Drug Delivery Systems.
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DOI：
10.1002/advs.201500437
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发表时间：
2016-07
期刊：
影响因子：
15.1
通讯作者：
Lim, May
中科院分区：
文献类型：
--
作者：
Bagheri, Ali;Arandiyan, Hamidreza;Boyer, Cyrille;Lim, May
在过去的五年里，使用近红外（NIR）光和上转换纳米颗粒（UCNPs）的药物递送系统（DDS）的开发引起了人们的强烈兴趣。这些NIR引发的DDS不仅提供了治疗释放的高度空间和时间确定，而且还提供了对释放剂量的精确控制。此外，这些纳米平台具有优于常规基于光的DDS的几个优点-NIR提供更好的组织穿透深度和降低的由暴露于高能量波长的光引起的细胞光损伤的风险（例如，紫外光，<400 nm）。可通过低强度NIR照明激活的DDS的开发是高度期望的，以避免将活组织暴露于可限制这些DDS的体内应用的过热。这包括三个方向的研究：（i）提高UCNPs的量子产率;（ii）将具有红移吸收的光响应材料掺入UCNPs;以及（iii）调谐UCNPs的激发波长。本文综述了近红外引发DDS的最新进展，重点是使用光响应化合物和聚合物材料结合到UCNPs。突出了限制UCNPs临床应用的挑战，以及为克服这些限制而出现的上述技术。
The development of drug delivery systems (DDSs) using near infrared (NIR) light and upconversion nanoparticles (UCNPs) has generated intensive interest over the past five years. These NIR‐initiated DDSs not only offer a high degree of spatial and temporal determination of therapeutic release but also provide precise control over the released dosage. Furthermore, these nanoplatforms confer several advantages over conventional light‐based DDSs—NIR offers better tissue penetration depth and a reduced risk of cellular photo‐damage caused by exposure to light at high‐energy wavelengths (e.g., ultraviolet light, <400 nm). The development of DDSs that can be activated by low intensity NIR illumination is highly desirable to avoid exposing living tissues to excessive heat that can limit the in vivo application of these DDSs. This encompasses research in three directions: (i) enhancing the quantum yield of the UCNPs; (ii) incorporation of photo‐responsive materials with red‐shifted absorptions into the UCNPs; and (iii) tuning the UCNPs excitation wavelength. This review focuses on recent advances in the development of NIR‐initiated DDS, with emphasis on the use of photo‐responsive compounds and polymeric materials conjugated onto UCNPs. The challenges that limit UCNPs clinical applications, alongside with the aforementioned techniques that have emerged to overcome these limitations, are highlighted.
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影响因子：
10.8
作者：
Chen G;Damasco J;Qiu H;Shao W;Ohulchanskyy TY;Valiev RR;Wu X;Han G;Wang Y;Yang C;Ågren H;Prasad PN
通讯作者：
Prasad PN
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影响因子：
62.1
作者：
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通讯作者：
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影响因子：
8.6
作者：
Argyo, Christian;Weiss, Veronika;Bein, Thomas
通讯作者：
Bein, Thomas
影响因子：
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作者：
Bogdan, Nicoleta;Vetrone, Fiorenzo;Capobianco, John A.
通讯作者：
Capobianco, John A.
原位聚合上转换发光NaYF4:Yb, Er(Tm)/PS块体透明纳米复合材料的制备及表征
影响因子：
9.9
作者：
Chai, Ruitao;Lian, Hongzhou;Lin, Jun
通讯作者：
Lin, Jun