Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: function, localization, and relevance to neurologic function.
Na-coupled bicarbonate transporters of the solute carrier 4 family in the nervous system: function, localization, and relevance to neurologic function.
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DOI：
10.1016/j.neuroscience.2010.09.037
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发表时间：
2010-12-29
期刊：
影响因子：
3.3
通讯作者：
Bevensee, M. O.
中科院分区：
文献类型：
--
作者：
Majumdar, D.;Bevensee, M. O.
许多细胞过程包括神经元活动对细胞内和/或细胞外pH的变化敏感，这两者都受酸碱转运蛋白活性的调节。HCO 3 −依赖性转运蛋白是神经元和星形胶质细胞中细胞内pH的特别有效的调节剂，也有助于脑脊液（CSF）的组成。HCO 3 −转运蛋白的分子生理学在过去的14年中取得了相当大的进展，因为研究人员已经克隆并表征了Slc 4家族（NCBTs）的许多Na偶联双链转运蛋白的功能和定位。在这篇综述中，我们提供了一个更新的概述的功能和定位的神经系统的NCBTs。多种NCBTs在不同脑区的神经元和星形胶质细胞以及脉络丛的上皮细胞中表达。SLC 4基因突变/缺失的人类患者的特征和最近对Slc 4基因破坏小鼠的研究结果突出了NCBTs在神经元活动、体感功能和CSF产生中的功能重要性。此外，能量不足的状态（例如，缺氧和缺血）导致NCBTs表达和活性改变。因此，最近的研究扩大了我们对NCBTs在调节神经系统的pH值和离子组成中的作用的理解，所述神经系统的pH值和离子组成可以调节神经元活动。
Many cellular processes including neuronal activity are sensitive to changes in intracellular and/or extracellular pH— both of which are regulated by acid-base transporter activity. HCO3−-dependent transporters are particularly potent regulators of intracellular pH in neurons and astrocytes, and also contribute to the composition of the cerebrospinal fluid (CSF). The molecular physiology of HCO3− transporters has advanced considerably over the past ~14 years as investigators have cloned and characterized the function and localization of many Na-Coupled Bicarbonate Transporters of the Slc4 family (NCBTs). In this review, we provide an updated overview of the function and localization of NCBTs in the nervous system. Multiple NCBTs are expressed in neurons and astrocytes in various brain regions, as well as in epithelial cells of the choroid plexus. Characteristics of human patients with SLC4 gene mutations/deletions and results from recent studies on mice with Slc4 gene disruptions highlight the functional importance of NCBTs in neuronal activity, somatosensory function, and CSF production. Furthermore, energy-deficient states (e.g., hypoxia and ischemia) lead to altered expression and activity of NCBTs. Thus, recent studies expand our understanding of the role of NCBTs in regulating the pH and ionic composition of the nervous system that can modulate neuronal activity.
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影响因子：
4.2
作者：
Cannizzaro, C;Monastero, R;Martire, M
通讯作者：
Martire, M
DOI：
10.1152/ajprenal.1998.274.6.f1119
发表时间：
1998-06-01
影响因子：
4.2
作者：
Burnham, CE;Flagella, M;Soleimani, M
通讯作者：
Soleimani, M
影响因子：
3.8
作者：
Bevensee, MO;Weed, RA;Boron, WF
通讯作者：
Boron, WF
影响因子：
5.5
作者：
BYERLY, L;MOODY, WJ
通讯作者：
MOODY, WJ
影响因子：
64.8
作者：
BORON, WF;HOGAN, E;RUSSELL, JM
通讯作者：
RUSSELL, JM