Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids.
Coordinated Modulation of Energy Metabolism and Inflammation by Branched-Chain Amino Acids and Fatty Acids.
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支链氨基酸和脂肪酸协调调节能量代谢和炎症
DOI：
10.3389/fendo.2020.00617
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发表时间：
2020
影响因子：
5.2
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Ye Z;Wang S;Zhang C;Zhao Y
支链氨基酸（BCAA）和脂肪酸（FAs）作为重要的代谢底物，沿着其代谢产物，参与线粒体生物合成、能量代谢、炎症反应等重要的生理过程。支链氨基酸和脂肪酸水平的增加可通过改变线粒体生物发生和三磷酸腺苷（ATP）的产生并干扰糖酵解、脂肪酸氧化、三羧酸循环（TCA）循环和氧化磷酸化而导致线粒体功能障碍。支链氨基酸可直接激活哺乳动物雷帕霉素靶蛋白（mTOR）信号通路，诱导胰岛素抵抗，也可与脂肪酸共同发挥作用。此外，支链氨基酸和脂肪酸水平升高可激活经典核因子-κB（NF-κB）信号通路和炎性小体，通过上调炎症信号调节线粒体功能障碍和代谢紊乱。本文全面总结了支链氨基酸和脂肪酸协同调节能量代谢、胰岛素敏感性和炎症的机制。
As important metabolic substrates, branched-chain amino acids (BCAAs) and fatty acids (FAs) participate in many significant physiological processes, such as mitochondrial biogenesis, energy metabolism, and inflammation, along with intermediate metabolites generated in their catabolism. The increased levels of BCAAs and fatty acids can lead to mitochondrial dysfunction by altering mitochondrial biogenesis and adenosine triphosphate (ATP) production and interfering with glycolysis, fatty acid oxidation, the tricarboxylic acid cycle (TCA) cycle, and oxidative phosphorylation. BCAAs can directly activate the mammalian target of rapamycin (mTOR) signaling pathway to induce insulin resistance, or function together with fatty acids. In addition, elevated levels of BCAAs and fatty acids can activate the canonical nuclear factor-κB (NF-κB) signaling pathway and inflammasome and regulate mitochondrial dysfunction and metabolic disorders through upregulated inflammatory signals. This review provides a comprehensive summary of the mechanisms through which BCAAs and fatty acids modulate energy metabolism, insulin sensitivity, and inflammation synergistically.
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影响因子：
64.8
作者：
Cunningham, John T.;Rodgers, Joseph T.;Puigserver, Pere
通讯作者：
Puigserver, Pere
DOI：
10.1152/ajpendo.00643.2010
发表时间：
2011-04-01
影响因子：
5.1
作者：
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作者：
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通讯作者：
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影响因子：
2
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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