Mechanism of action of lenalidomide in hematological malignancies.
Mechanism of action of lenalidomide in hematological malignancies.
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DOI：
10.1186/1756-8722-2-36
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发表时间：
2009-08-12
影响因子：
28.5
通讯作者：
Verma A
中科院分区：
文献类型：
--
作者：
Kotla V;Goel S;Nischal S;Heuck C;Vivek K;Das B;Verma A
免疫调节药物来那度胺和泊马度胺是通过修改沙利度胺的化学结构衍生的合成化合物，以提高其效力并减少其副作用。来那度胺是沙利度胺的 4-氨基-谷氨酰类似物，没有镇静和神经病变等神经系统副作用，已成为一种具有抗各种血液和实体恶性肿瘤活性的药物。它已被 FDA 批准临床用于治疗 5q 染色体缺失的骨髓增生异常综合征和多发性骨髓瘤。来那度胺已被证明是一种免疫调节剂，影响免疫系统的细胞和体液分支。它还被证明具有抗血管生成特性。较新的研究证明了它对信号转导的影响，这可以部分解释它对 MDS 子集的选择性功效。尽管来那度胺的确切分子靶点尚不清楚，但其在一系列肿瘤疾病中的活性凸显了多个靶点作用的可能性。
Immunomodulatory drugs lenalidomide and pomalidomide are synthetic compounds derived by modifying the chemical structure of thalidomide to improve its potency and reduce its side effects. Lenalidomide is a 4-amino-glutamyl analogue of thalidomide that lacks the neurologic side effects of sedation and neuropathy and has emerged as a drug with activity against various hematological and solid malignancies. It is approved by FDA for clinical use in myelodysplastic syndromes with deletion of chromosome 5q and multiple myeloma. Lenalidomide has been shown to be an immunomodulator, affecting both cellular and humoral limbs of the immune system. It has also been shown to have anti-angiogenic properties. Newer studies demonstrate its effects on signal transduction that can partly explain its selective efficacy in subsets of MDS. Even though the exact molecular targets of lenalidomide are not well known, its activity across a spectrum of neoplastic conditions highlights the possibility of multiple target sites of action.
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影响因子：
78.5
作者：
Bartlett, JB;Dredge, K;Dalgleish, AG
通讯作者：
Dalgleish, AG
影响因子：
15.8
作者：
Ebert, Benjamin L.;Galili, Naomi;Raza, Azra
通讯作者：
Raza, Azra
影响因子：
3.1
作者：
Dredge, K;Horsfall, R;Bartlett, JB
通讯作者：
Bartlett, JB
影响因子：
20.3
作者：
Dispenzieri, Angela;Lacy, Martha Q.;Gertz, Morie A.
通讯作者：
Gertz, Morie A.
影响因子：
64.8
作者：
Ebert, Benjamin L.;Pretz, Jennifer;Bosco, Jocelyn;Chang, Cindy Y.;Tamayo, Pablo;Galili, Naomi;Raza, Azra;Root, David E.;Attar, Eyal;Ellis, Steven R.;Golub, Todd R.
通讯作者：
Golub, Todd R.