Sleep apnoea in the elderly: a great challenge for the future.
Sleep apnoea in the elderly: a great challenge for the future.
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DOI：
10.1183/13993003.01649-2021
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Rapoport DM
中科院分区：
文献类型：
--
作者：
Osorio RS;Martínez-García MÁ;Rapoport DM
部分由于健康状况的全面改善，老年人口正在迅速增加。同样，阻塞性睡眠呼吸暂停（OSA）不仅得到越来越多的认识，而且由于全球肥胖的流行而增加。OSA与衰老重叠较大，但两方面的因果关系都有很强的合理性：OSA与可能加速衰老的病理过程和衰老相关过程有关；衰老可能会导致身体和神经系统的变化，导致阻塞性（和中枢性）呼吸暂停。此外，OSA的常见症状（如白天嗜睡、记忆和认知缺陷）、可能的生理后果（如心脑血管动脉粥样硬化加速）以及代谢和炎症标志物的变化与衰老中出现的症状和相关情况重叠。这些症状和条件对生活质量的影响也有协同作用的可能性，并且需要将阻塞性睡眠呼吸暂停的可治疗后果与年龄相关的主诉分开。综上所述，有必要回顾OSA与衰老的相互作用，无论是已证实的还是怀疑的。本审查审查了已知情况的某些方面，并指出有必要进一步调查这些关系，因为有大量可能受影响的对象。
Due in part to overall improvements in health, the population of elderly individuals is increasing rapidly. Similarly, obstructive sleep apnoea (OSA) is both gaining increased recognition and also increasing due to the worldwide obesity epidemic. The overlap of OSA and aging is large, but there is strong plausibility for causation in both directions: OSA is associated with pathological processes that may accelerate aging and aging related processes; aging may cause physical and neurological changes that predispose to obstructive (and central) apnoea. In addition, the common symptoms (e.g. excessive daytime somnolence, defects in memory and cognition), possible physiological consequences of OSA (e.g. accelerated cardiovascular and cerebrovascular atherosclerosis), and changes in metabolic and inflammatory markers overlap with the symptoms and associated conditions seen in aging. There is also the possibility of synergy in the effects of these symptoms and conditions on quality of life, as well as a need to separate treatable consequences of OSA from age-related complaints. Taken together, the above make it essential to review the interaction of OSA and aging, both proven and suspected. The present review examines some aspects of what is known and points to the need for further investigation of the relationships, given the large number of potentially affected subjects.
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DOI：
10.1093/geronj/45.5.m169
发表时间：
1990-09-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
BERRY, DTR;PHILLIPS, BA;ALLEN, RS
通讯作者：
ALLEN, RS
影响因子：
6.3
作者：
Blackwell T;Yaffe K;Laffan A;Redline S;Ancoli-Israel S;Ensrud KE;Song Y;Stone KL;Osteoporotic Fractures in Men Study Group
通讯作者：
Osteoporotic Fractures in Men Study Group
影响因子：
2.5
作者：
Alchanatis, Manos;Zias, Nikolaos;Roussos, Charis
通讯作者：
Roussos, Charis
影响因子：
8.3
作者：
Catalan-Serra, Pablo;Campos-Rodriguez, Francisco;Martinez-Garcia, Miguel A.
通讯作者：
Martinez-Garcia, Miguel A.
影响因子：
6.9
作者：
Castro-Grattoni, Anabel L.;Suarez-Giron, Monique;Sanchez-De-La-Torre, Manuel
通讯作者：
Sanchez-De-La-Torre, Manuel