Comorbidities and Health-Related Quality of Life in Subjects with Spine Osteoarthritis at 50 Years of Age or Older: Data from the Korea National Health and Nutrition Examination Survey.
Comorbidities and Health-Related Quality of Life in Subjects with Spine Osteoarthritis at 50 Years of Age or Older: Data from the Korea National Health and Nutrition Examination Survey.
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DOI：
10.3390/medicina58010126
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发表时间：
2022-01-14
期刊：
影响因子：
--
通讯作者：
Choe JY
中科院分区：
文献类型：
--
作者：
Kim SK;Choe JY
背景与目的：本研究评估韩国人群腰椎骨关节炎（OA）患者的合并症和健康相关生活质量（HRQOL）。材料和方法：我们分析了3256名年龄在50岁或以上的受试者，作为2012年韩国国家健康和营养调查（KNHANES）的一部分，他们接受了腰椎x线平片检查。影像学评估基于Kellgren-Lawrence （K-L）评分0 - 2级，其中K-L评分2级定义为腰椎OA。HRQOL采用EuroQol-5维度（EQ-5D）评估，包括EQ-5D指数和视觉模拟量表（EQ-VAS）测量。结果：与对照组相比，脊柱骨性关节炎患者高血压、心肌梗死、心绞痛、脑梗死、糖尿病等合并症发生率较高，而血脂异常发生率较低。脊柱OA患者的平均合并症数量高于对照组（1.40 （SE 0.05）比1.20 (SE 0.03), p = 0.001）。脊柱OA患者的EQ-5D指数明显低于对照组（p < 0.001），但EQ-VAS评分不低于对照组。多因素logistic分析显示，与对照组相比，高血压和结肠癌与脊柱骨关节炎相关（OR为1.219,95% CI为1.020-1.456,p = 0.030； OR为0.200,95% CI为0.079-0.505,p = 0.001）。较低的EQ-5D指数与脊柱OA相关（95% CI 0.256, 95% CI 0.110-0.595, p = 0.002），但与EQ-VAS评分无关。结论：在本研究中，我们发现高血压、结肠癌等合并症以及较低的HRQOL与脊柱OA相关。
Background and Objective: This study assessed comorbidities and health-related quality of life (HRQOL) in subjects with lumbar spine osteoarthritis (OA) in the Korean population. Materials and Methods: We analyzed 3256 subjects who were 50 years or older and underwent plain radiography of the lumbar spine as part of the Korea National Health and Nutrition Examination Survey (KNHANES) 2012. Radiographic assessment was based on Kellgren–Lawrence (K-L) grade ranging from 0 to 2, with K-L grade 2 defined as lumbar spine OA. HRQOL was assessed by EuroQol-5 dimensions (EQ-5D), which include the EQ-5D index and visual analogue scale (EQ-VAS) measurements. Results: Comorbidities such as hypertension, myocardial infarction, angina, cerebral infarction, and diabetes mellitus were more frequent in spine OA than in controls, while dyslipidemia was less common. Subjects with spine OA had higher mean number of comorbid conditions than controls (1.40 (SE 0.05) vs. 1.20 (SE 0.03), p = 0.001). Subjects with spine OA had much lower EQ-5D index than controls (p < 0.001) but not lower EQ-VAS score. Multivariate binary logistic analysis showed that hypertension and colon cancer were associated with spine OA compared to controls (OR 1.219, 95% CI 1.020–1.456, p = 0.030 and OR 0.200, 95% CI 0.079–0.505, p = 0.001, respectively) after adjustment for confounding factors. Lower EQ-5D index was related to spine OA (95% CI 0.256, 95% CI 0.110–0.595, p = 0.002) but not EQ-VAS score. Conclusion: In this study, we found that comorbidities such as hypertension and colon cancer as well as lower HRQOL were associated with spine OA.
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影响因子：
3.7
作者：
Jeong H;Baek SY;Kim SW;Eun YH;Kim IY;Lee J;Jeon CH;Koh EM;Cha HS
通讯作者：
Cha HS
影响因子：
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作者：
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Lix, Lisa
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影响因子：
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作者：
KELLGREN, JH;LAWRENCE, JS
通讯作者：
LAWRENCE, JS