Signatures and Clinical Significance of Amino Acid Flux in Sarcopenia: A Systematic Review and Meta-Analysis.
Signatures and Clinical Significance of Amino Acid Flux in Sarcopenia: A Systematic Review and Meta-Analysis.
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DOI：
10.3389/fendo.2021.725518
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发表时间：
2021
影响因子：
5.2
通讯作者：
Dai L
中科院分区：
文献类型：
--
作者：
Dai M;Lin T;Yue J;Dai L
氨基酸的失调与肌少症的发生和发展密切相关。本文综述了肌少症中氨基酸谱的最新研究进展，系统地介绍了氨基酸通量在肌少症中的临床意义。我们系统地检索了MEDLINE， EMBASE和Cochrane文库，从成立到2021年6月1日，以捕获所有检查肌肉减少症代谢组学的研究。我们使用了以下关键词：肌肉减少症、代谢组学、代谢组学、氨基酸谱和质谱。比较肌少症患者和非肌少症患者之间氨基酸模式的原始文章被纳入。两名独立研究者独立完成标题和摘要筛选、数据提取和质量评估。我们使用随机效应模型来检验氨基酸水平和肌肉减少症之间的关系。敏感性分析将分析限制在通过生物电阻抗分析测量肌肉质量的研究中。研究质量根据医疗保健研究和质量机构（AHRQ）检查表进行评估。系统研究产生了6篇符合条件的文章，包括1120名参与者。5项研究将肌肉质量与身体表现和/或肌肉力量结合作为诊断肌肉减少症的标准，1项研究将肌肉质量单独作为诊断标准。我们发现，支链氨基酸亮氨酸（标准化平均差[SMD] -1.249, 95%可信区间[CI]: -2.275, -0.223, P = 0.02, I2 = 97.7%）、异亮氨酸（SMD -1.077, 95% CI: -2.106, -0.049, P = 0.04, I2 = 97.8%）和芳香氨基酸色氨酸（SMD -0.923, 95% CI: -1.580, -0.265, P = 0.01, I2 = 89.9%）的浓度在肌少症患者中显著降低。研究结果在敏感性分析中是稳健的。氨基酸的体内平衡对维持肌肉健康至关重要。氨基酸谱可能是肌少症表征的有用生物标志物。进一步研究氨基酸在肌少症诊断和治疗中的临床意义是值得的。
Dysregulation of amino acids is closely linked to the initiation and progression of sarcopenia. We summarized recent advancements in the studies of amino acid profiles in sarcopenia and systematically presented the clinical significance of amino acid flux in sarcopenia. We systematically searched in MEDLINE, EMBASE, and Cochrane library from inception to June 1, 2021 to capture all studies examining metabolomics of sarcopenia. We used the following keywords: sarcopenia, metabonomics, metabolomics, amino acid profile, and mass spectrometry. Original articles comparing amino acid patterns between persons with and without sarcopenia were included. Two independent investigators independently completed title and abstract screening, data extraction, and quality evaluation. We used a random effects model to examine the association between amino acids levels and sarcopenia. Sensitivity analyses restricted the analyses to studies in which muscle mass was measured by bioelectrical impedance analysis. Study quality was evaluated according to the Agency for Healthcare Research and Quality (AHRQ) checklist. The systematic research yielded six eligible articles, comprising 1,120 participants. Five studies used muscle mass in combination with physical performance and/or muscle strength as the criteria to diagnose sarcopenia, while one study used muscle mass as a diagnostic criterion alone. We found that the concentrations of branched-chain amino acids leucine (standardized mean difference [SMD] -1.249; 95% confidence interval [CI]: -2.275, -0.223, P = 0.02, I2 = 97.7%), isoleucine (SMD -1.077; 95% CI: -2.106, -0.049, P = 0.04, I2 = 97.8%), and aromatic amino acid tryptophan (SMD -0.923; 95% CI: -1.580, -0.265, P = 0.01, I2 = 89.9%) were significantly reduced in individuals with sarcopenia. Study results were robust in sensitivity analysis. The homeostasis of amino acids is critical to maintaining muscle health. The profiles of amino acids might be useful biomarkers for the characterization of sarcopenia. Future studies are warranted to study the clinical significance of amino acids in the diagnosis and treatment of sarcopenia.
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DOI：
10.1016/j.nut.2015.02.011
发表时间：
2015-07
期刊：
Nutrition (Burbank, Los Angeles County, Calif.)
影响因子：
--
作者：
Dukes A;Davis C;El Refaey M;Upadhyay S;Mork S;Arounleut P;Johnson MH;Hill WD;Isales CM;Hamrick MW
通讯作者：
Hamrick MW
影响因子：
8.8
作者：
Chantranupong L;Wolfson RL;Orozco JM;Saxton RA;Scaria SM;Bar-Peled L;Spooner E;Isasa M;Gygi SP;Sabatini DM
通讯作者：
Sabatini DM
异亮氨酸通过促进肌肉生成和肌细胞内脂肪沉积来增加肌肉质量
影响因子：
6.1
作者：
Liu, Shuge;Sun, Yunmei;Pang, Weijun
通讯作者：
Pang, Weijun
影响因子：
6.7
作者：
Landi, Francesco;Cruz-Jentoft, Alfonso J.;Onder, Graziano
通讯作者：
Onder, Graziano
影响因子：
6.3
作者：
Borsheim, Elisabet;Bui, Quynh-Uyen T.;Wolfe, Robert R.
通讯作者：
Wolfe, Robert R.