Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.
Cytokines and neurodevelopmental outcomes in extremely low birth weight infants.
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DOI：
10.1016/j.jpeds.2011.05.042
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发表时间：
2011-12
影响因子：
5.1
通讯作者：
Higgins, Rosemary D.
中科院分区：
文献类型：
--
作者：
Carlo, Waldemar A.;McDonald, Scott A.;Tyson, Jon E.;Stoll, Barbara J.;Ehrenkranz, Richard A.;Shankaran, Seetha;Goldberg, Ronald N.;Das, Abhik;Schendel, Diana;Thorsen, Poul;Skogstrand, Kristin;Hougaard, David M.;Oh, William;Laptook, Abbot R.;Duara, Shahnaz;Fanaroff, Avroy A.;Donovan, Edward F.;Korones, Sheldon B.;Stevenson, David K.;Papile, Lu-Ann;Finer, Neil N.;O'Shea, T. Michael;Poindexter, Brenda B.;Wright, Linda L.;Ambalavanan, Namasivayam;Higgins, Rosemary D.
确定是否选定的促炎和抗炎细胞因子/炎症介质报告与脑瘫的发展预测极低出生体重儿的神经发育结果。出生体重≤ 1000 g的婴儿（n=1067）在出生时和第3±1、7±1、14±3和21±3天采集血样，以检查细胞因子与神经发育结局之间的相关性。分析集中于5种细胞因子（IL-1β、IL-8、TNF-α、RANTES和IL-2），据报告，这些细胞因子最能预测足月和晚期早产儿的CP。在未调整和调整分析中，与未发生CP的婴儿相比，发生CP的婴儿在第0-4天以及随后的IL-8较高。其他细胞因子（IL-12、IL-17、TNF-β、SIL-rα、MIP-1β）在0-4天发生变化。CP在前早产儿可能，部分，有一个晚期围产期和/或早期新生儿炎症起源。
To determine if selected pro-inflammatory and anti-inflammatory cytokines/mediators of inflammation reported to be related to development of cerebral palsy predict neurodevelopmental outcome in extremely low birth weight infants. Infants with birth weights ≤ 1000 g (n=1067) had blood samples collected at birth and on days 3±1, 7±1, 14±3, and 21±3 to examine the association between cytokines and neurodevelopmental outcomes. The analyses were focused on five cytokines (IL-1β, IL-8, TNF-α, RANTES, and IL-2) reported to be most predictive of CP in term and late preterm infants. IL-8 was higher on days 0–4 and subsequently in infants who developed CP compared with infants who did not develop CP in both unadjusted and adjusted analyses. Other cytokines (IL-12, IL-17, TNF-β, SIL-rα, MIP-1β) were found to be altered on days 0–4 in infants who developed CP. CP in former preterm infants may, in part, have a late perinatal and/or early neonatal inflammatory origin.
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影响因子：
2.1
作者：
Dammann O;O'Shea TM
通讯作者：
O'Shea TM
影响因子：
3.6
作者：
Bartha, AI;Foster-Barber, A;Ferriero, DM
通讯作者：
Ferriero, DM
影响因子：
158.5
作者：
Baud, O;Foix-L'Helias, L;Lacaze-Masmonteil, T
通讯作者：
Lacaze-Masmonteil, T
影响因子：
11.2
作者：
Kaukola, T;Satyaraj, E;Hallman, M
通讯作者：
Hallman, M
影响因子：
3.8
作者：
Garau, A;Bertini, R;Villa, P
通讯作者：
Villa, P