Exploiting herpes simplex virus entry for novel therapeutics.
Exploiting herpes simplex virus entry for novel therapeutics.
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DOI：
10.3390/v5061447
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发表时间：
2013-06-10
期刊：
影响因子：
--
通讯作者：
Shukla D
中科院分区：
文献类型：
--
作者：
Hadigal S;Shukla D
单纯疱疹病毒（HSV）与多种疾病如生殖器疱疹和许多眼部疾病有关。在全球一级，HSV血清反应阳性者的高流行率，加上其不明显的感染，仍然是一个令人严重关切的问题。在分子水平上，HSV进入宿主细胞涉及多个步骤，主要是病毒糖蛋白与各种细胞表面受体的相互作用，其中许多受体具有替代替代物。病毒进入细胞的分子复杂性也因不同病毒进入模式的存在而增强。许多进入受体的可用性，沿着各种进入机制，已经导致能够感染几乎所有细胞类型的病毒。虽然HSV使用广泛的病毒和宿主因子来建立感染，但目前针对病毒的治疗方法并不多样化。在这篇特别的综述中，我们将重点关注病毒进入细胞的最初过程，同时强调可以控制这一过程的潜在新疗法。病毒进入是决定性的一步，有效的治疗方法可以转化为更少的病毒复制，减少细胞死亡和有害症状。
Herpes Simplex virus (HSV) is associated with a variety of diseases such as genital herpes and numerous ocular diseases. At the global level, high prevalence of individuals who are seropositive for HSV, combined with its inconspicuous infection, remains a cause for major concern. At the molecular level, HSV entry into a host cell involves multiple steps, primarily the interaction of viral glycoproteins with various cell surface receptors, many of which have alternate substitutes. The molecular complexity of the virus to enter a cell is also enhanced by the existence of different modes of viral entry. The availability of many entry receptors, along with a variety of entry mechanisms, has resulted in a virus that is capable of infecting virtually all cell types. While HSV uses a wide repertoire of viral and host factors in establishing infection, current therapeutics aimed against the virus are not as diversified. In this particular review, we will focus on the initial entry of the virus into the cell, while highlighting potential novel therapeutics that can control this process. Virus entry is a decisive step and effective therapeutics can translate to less virus replication, reduced cell death, and detrimental symptoms.
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DOI：
10.1073/pnas.0707452104
发表时间：
2007-11-20
影响因子：
11.1
作者：
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影响因子：
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DOI：
10.2174/1568005054880127
发表时间：
2005-09-01
期刊：
Current Drug Targets - Infectious Disorders
影响因子：
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作者：
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通讯作者：
Schengrund, C.-L.
影响因子：
5.4
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作者：
Atanasiu, Doina;Whitbeck, J. Charles;Eisenberg, Roselyn J.
通讯作者：
Eisenberg, Roselyn J.