The ChEMBL bioactivity database: an update.

The ChEMBL bioactivity database: an update.
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DOI:
10.1093/nar/gkt1031
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发表时间:
2014-01
影响因子:
14.9
通讯作者:
Overington JP
Overington JP
中科院分区:
生物学2区
文献类型:
--
作者:
Bento AP;Gaulton A;Hersey A;Bellis LJ;Chambers J;Davies M;Krüger FA;Light Y;Mak L;McGlinchey S;Nowotka M;Papadatos G;Santos R;Overington JP

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ChEMBL是一个开放的大规模生物活性数据库(https://www.ebi.ac.uk/chembl),先前在2012年核酸研究数据库问题中进行了描述。从那时起,各种新的数据源和功能的改进促进了资源的增长和效用。特别是,通过纳入美国采用名称申请的数据,对化合物从研究阶段到临床开发再到上市的过程进行了更全面的跟踪;开发了一个新的更丰富的数据模型,用于表示药物目标;并制定了一些方法,使用户能够更容易地确定可靠的数据。最后,除了基于网络的界面、数据下载和网络服务之外,现在还可以通过新的资源描述框架格式访问ChEMBL。
ChEMBL is an open large-scale bioactivity database (https://www.ebi.ac.uk/chembl), previously described in the 2012 Nucleic Acids Research Database Issue. Since then, a variety of new data sources and improvements in functionality have contributed to the growth and utility of the resource. In particular, more comprehensive tracking of compounds from research stages through clinical development to market is provided through the inclusion of data from United States Adopted Name applications; a new richer data model for representing drug targets has been developed; and a number of methods have been put in place to allow users to more easily identify reliable data. Finally, access to ChEMBL is now available via a new Resource Description Framework format, in addition to the web-based interface, data downloads and web services.
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