Hippocampal and rostral anterior cingulate blood flow is associated with affective symptoms in chronic traumatic brain injury.
Hippocampal and rostral anterior cingulate blood flow is associated with affective symptoms in chronic traumatic brain injury.
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DOI：
10.1016/j.brainres.2021.147631
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发表时间：
2021-11-15
期刊：
影响因子：
2.9
通讯作者：
Ding K
中科院分区：
文献类型：
--
作者：
Thomas BP;Tarumi T;Wang C;Zhu DC;Tomoto T;Munro Cullum C;Dieppa M;Diaz-Arrastia R;Bell K;Madden C;Zhang R;Ding K
本研究旨在评估慢性创伤性脑损伤（TBI）患者的脑血流量（CBF）及其与自我报告症状的相关性。16名轻度至重度TBI和持续自我报告的神经系统症状的参与者，受伤后6至72个月。为了进行比较，还包括16名年龄和性别匹配的健康正常对照参与者。分别使用伪连续动脉自旋标记（PCASL）和T1加权数据评估局部CBF和脑体积。分别使用美国国立卫生研究院（NIH）的认知测验和患者报告结果测量信息系统评估TBI参与者的认知功能和自我报告的症状。评估CBF与认知功能、症状的关系。两组之间的总体CBF和局部脑体积相似，但感兴趣区域（ROI）分析显示TBI组双侧丘脑、海马、左尾状核和左杏仁核的CBF较低。体素分析显示，CBF在海马，海马旁，喙前扣带回，额下回，和其他颞区与自我报告的愤怒，焦虑和抑郁症状呈负相关。此外，感兴趣区（ROI）分析显示，海马和头端前扣带回CBF与疲劳，焦虑，抑郁和睡眠问题的症状呈负相关。与正常对照组（NC）相比，慢性TBI组中观察到区域CBF缺损，尽管大脑结构体积相似。观察到的区域CBF和情感症状之间的负相关性表明，CBF靶向干预可能会改善TBI后的情感症状和生活质量，这需要在未来的研究中进行评估。
The purpose of this study was to assess cerebral blood flow (CBF) and its association with self-reported symptoms in chronic traumatic brain injury (TBI). Sixteen participants with mild to severe TBI and persistent self-reported neurological symptoms, 6 to 72 months post-injury were included. For comparison, 16 age- and gender-matched healthy normal control participants were also included. Regional CBF and brain volume were assessed using pseudo-continuous Arterial Spin Labeling (PCASL) and T1-weighted data respectively. Cognitive function and self-reported symptoms were assessed in TBI participants using the national institutes of health (NIH) Toolbox Cognition Battery and Patient-Reported Outcome Measurement Information System respectively. Associations between CBF and cognitive function, symptoms were assessed. Global CBF and regional brain volumes were similar between groups, but region of interest (ROI) analysis revealed lower CBF bilaterally in the thalamus, hippocampus, left caudate, and left amygdala in the TBI group. Voxel-wise analysis revealed that CBF in the hippocampus, parahippocampus, rostral anterior cingulate, inferior frontal gyrus, and other temporal regions were negatively associated with self-reported anger, anxiety, and depression symptoms. Furthermore, region of interest (ROI) analysis revealed that hippocampal and rostral anterior cingulate CBF were negatively associated with symptoms of fatigue, anxiety, depression, and sleep issues. Regional CBF deficit was observed in the group with chronic TBI compared to the normal control (NC) group despite similar volume of cerebral structures. The observed negative correlation between regional CBF and affective symptoms suggests that CBF-targeted intervention may potentially improve affective symptoms and quality of life after TBI, which needs to be assessed in future studies.
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